ArticleJournal of community hospital internal medicine perspectives2016
Guillain-Barré syndrome occurring synchronously with systemic lupus erythematosus as initial manifestation treated successfully with low-dose cyclophosphamide.
Article in Journal of community hospital internal medicine perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Qualitative evaluation of pharmacological strategy for connective tissue diseases with Guillain-Barré syndrome: a systematic review.Frontiers in immunology · 2026Pooled it
- Cyclophosphamide in the Treatment of Systemic Lupus Erythematosus-related Guillain-Barré Syndrome: A Systematic Review of Case Reports.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023Pooled it
- From Nerve to Autoimmunity: Acute Guillain-Barré Syndrome in a 4-Year-Old with Early-Onset Pediatric Systemic Lupus Erythematosus.Open access rheumatology : research and reviews · 2026Article
- Clinical features of Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuritis associated with SLE.Lupus science & medicine · 2024Article
- Case Report: Guillain-Barré Syndrome as Primary Presentation of Systemic Lupus Erythematosus (SLE-GBS) in a Teenage Girl.Frontiers in pediatrics · 2022Article
- Fulminant Guillain-Barré syndrome in a patient with systemic lupus erythematosus.BMJ case reports · 2019Article
- Guillain-Barre syndrome as the first manifestation of juvenile systemic lupus erythematosus: a case report.Open access rheumatology : research and reviews · 2019Article
- Acute bilateral vision deficit as the initial symptom in Guillain-Barre syndrome: A case report.Experimental and therapeutic medicine · 2018Article
- Guillain-Barré Syndrome as an Initial Manifestation of Systemic Lupus Erythematous: Rare Case Report.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic lupus erythematous (SLE) is frequently encountered in clinical practice; a widespread immunological response can involve any organ system, sometimes leading to rare and diagnostically challenging presentations. We describe a 38-year-old female who presented with symmetric numbness and tingling of the hands and feet, and cervical pain. Imaging studies were not diagnostic of any serious underlying pathology. The patient developed ascending paresis involving lower extremities and cranial muscles (dysphagia and facial weakness). Guillain-Barré syndrome (GBS) was diagnosed on the basis of electromyography and lumbar puncture showing albuminocytologic dissociation. Intravenous immunoglobulins (IVIG) were administered for 5 days. Supported by anti-dsDNA antibody, oral ulcers, proteinuria of 0.7 g in 24 h, and neurological manifestation, she was diagnosed with lupus. After completion of IVIG, she received pulse-dose corticosteroids and one dose of low-dose cyclophosphamide. Her neurological symptoms improved and she had complete neurological recovery several months after her initial presentation. Literature search provides evidence of co-occurrence of lupus and GBS occurring mostly later in the course of the disease. However, GBS as initial manifestation of SLE is exceedingly rare and less understood. The association of GBS with lupus is important to recognize for rapid initiation of appropriate therapy and for consideration of immunosuppressive therapy which may affect the outcome.
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