ArticleObesity (Silver Spring, Md.)2016
Fitness, insulin sensitivity, and frontal lobe integrity in adults with overweight and obesity.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Brain and behavioral correlates of insulin resistance in youth with depression and obesity.Hormones and behavior · 2019Trial
- Insulin resistance and metabolic health predict cardiorespiratory fitness: cohort study.European heart journal open · 2026Article
- Sex modifies the association between cardiorespiratory fitness and insulin resistance in adults at risk for Alzheimer's disease.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2025Observational
- Article
- Insulin Homeostasis Mediates the Relationship Between Cardiorespiratory Fitness and Cognitive Speed in Aging Adults.Journal of Alzheimer's disease : JAD · 2023Observational
- Usefulness of an Easy, Structured, and Home-Based Exercise Program to Improve Physical Performance and Quality of Life in a Patient's Cohort with Obesity.Obesity facts · 2023Article
- Relationships between physical activity, healthy eating and cortical thickness in children and young adults.Brain imaging and behavior · 2022Article
- Role of Cardiovascular Risk Factors on the Association Between Physical Activity and Brain Integrity Markers in Older Adults.Neurology · 2022Article
- Pre-diabetes is associated with altered functional connectivity density in cortical regions of the default-mode network.Frontiers in aging neuroscience · 2022Article
- Does obesity-associated insulin resistance affect brain structure and function of adolescents differentially by sex?Psychiatry research. Neuroimaging · 2022Article
- Demographic and Socioeconomic Determinants of Body Mass Index in People of Working Age.International journal of environmental research and public health · 2020Article
- Fatty Acids, Antioxidants and Physical Activity in Brain Aging.Nutrients · 2017Review
- Insulin Sensitivity and Inflammation Mediate the Impact of Fitness on Cerebrovascular Health in Adolescents.Childhood obesity (Print) · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo formally test whether insulin sensitivity mediates the relationship between fitness and brain integrity.
methodsEighty-four middle-aged participants without diabetes received a 6-min walk test from which maximal oxygen uptake (VO2 max) was derived, a structural magnetic resonance scan, and a medical evaluation including fasting glucose and insulin levels.
resultsThis study showed significant associations between fitness, abdominal obesity, and insulin sensitivity and anterior cingulate cortex (ACC) volume as well as between ACC thickness and quantitative insulin-sensitivity check index (QUICKI). The relationship between ACC volume and VO2 max was completely mediated through QUICKI. Further, this strong association was confirmed by a single and very significant cluster on the ACC linking gray matter volume and QUICKI in a voxel-based morphometry analysis.
conclusionsAs expected, increased abdominal obesity was associated with reductions in fitness, ACC volumes, and insulin sensitivity. Importantly, this study demonstrated a significant mediation of the relationship between VO2 max and ACC volume by QUICKI. This suggests that the links between impaired insulin sensitivity and brain abnormalities in adults carrying excess weight could be alleviated through increased physical activity and fitness.
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