Evidence map›Paper›PMID 27123852›Full record

ArticlePloS one2016

Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources.

Ravi Shah, Kahraman Tanriverdi, Daniel Levy, Martin Larson, Mark Gerstein, Eric Mick, Joel Rozowsky, Robert Kitchen, Venkatesh Murthy, Ekaterina Mikalev and 1 more

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Mapping circulating serum miRNAs to their immune-related target mRNAs.Advances and applications in bioinformatics and chemistry : AABC · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ravi ShahCardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, 02215, United States of America.
Kahraman TanriverdiUniversity of Massachusetts Medical School, Department of Medicine, Division of Cardiovascular Medicine, Worcester, MA, 01605, United States of America.
Daniel LevyThe Framingham Heart Study, Framingham, MA, United States of America and Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
Martin LarsonThe Framingham Heart Study, Framingham, MA, United States of America and Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
Mark GersteinYale University Medical School, Computational Biology & Bioinformatics Program, New Haven, CT, 06520, United States of America.
Eric MickUniversity of Massachusetts Medical School, Department of Quantitative Health Sciences, Worcester, MA, 01605, United States of America.
Joel RozowskyYale University Medical School, Computational Biology & Bioinformatics Program, New Haven, CT, 06520, United States of America.
Robert KitchenYale University Medical School, Computational Biology & Bioinformatics Program, New Haven, CT, 06520, United States of America.
Venkatesh MurthyDepartment of Cardiology, University of Michigan, Ann Arbor, Michigan, 1500 E. Medical Center Dr. SPC 5873, Ann Arbor, MI, 48109, United States of America.
Ekaterina MikalevUniversity of Massachusetts Medical School, Department of Medicine, Division of Cardiovascular Medicine, Worcester, MA, 01605, United States of America.
Jane E FreedmanUniversity of Massachusetts Medical School, Department of Medicine, Division of Cardiovascular Medicine, Worcester, MA, 01605, United States of America.

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
University of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0M
Racial and Ethnic Diversity in Human Extracellular RNAU01HL126495 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEDMAN, JANE E, GERSTEIN, MARK BENDER · 2014 to 2018
$3.4M
Extracellular RNAs: Biomarkers for Cardiovascular Risk and DiseaseUH3TR000921 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEDMAN, JANE E · 2015 to 2017
$3.1M
Extracellular RNAs: Biomarkers for Cardiovascular Risk and DiseaseUH2TR000921 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FREEDMAN, JANE E · 2013 to 2014
$1.0M
Myocardial tissue architecture in heart failure: implications on physiology and fitnessK23HL127099 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SHAH, RAVI · 2016 to 2019
$668k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NCATS NIH HHS UH2 TR000921NCATS NIH HHS UH3 TR000921NCATS NIH HHS UL1 TR001453NHLBI NIH HHS K23 HL127099NHLBI NIH HHS N01 HC025195NHLBI NIH HHS U01 HL126495
6 · The paper itself

Abstract

MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.

Indexed as

BiomarkersCardiovascular DiseasesHumansMicroRNAsPlasmaProspective StudiesBiomarkersMicroRNAs

Identifiers

PMID27123852
PMCPMC4849639

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.