ArticleJournal of psychiatric practice2016
Use of the Temperament and Character Inventory to Predict Response to Repetitive Transcranial Magnetic Stimulation for Major Depression.
Article in Journal of psychiatric practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of Personality Styles on Clinical Response to Intermittent Theta Burst Stimulation for Depression.Journal of clinical medicine · 2025Article
- Regulatory Clearance and Approval of Therapeutic Protocols of Transcranial Magnetic Stimulation for Psychiatric Disorders.Brain sciences · 2023Review
- Response to TMS treatment for depression associated with higher levels of psychological well-being.Journal of psychiatric research · 2022Article
- Type D Personality, Stress Level, Life Satisfaction, and Alcohol Dependence in Older Men.Frontiers in psychiatry · 2021Article
- The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings.Translational psychiatry · 2019Review
- Personalized repetitive transcranial magnetic stimulation temporarily alters default mode network in healthy subjects.Scientific reports · 2019Article
- Predictors of Response to Repetitive Transcranial Magnetic Stimulation in Depression: A Review of Recent Updates.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Review
- The influence of personality on the effect of iTBS after being stressed on cortisol secretion.PloS one · 2019Article
- Early vulnerabilities for psychiatric disorders in elementary schoolchildren from four Brazilian regions.Social psychiatry and psychiatric epidemiology · 2018Article
- Personality Characteristics as Predictive Factors for the Occurrence of Depressive Disorder.Open access Macedonian journal of medical sciences · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe goal of this study was to investigate the utility of the Temperament and Character Inventory (TCI) in predicting antidepressant response to repetitive transcranial magnetic stimulation (rTMS).
backgroundAlthough rTMS of the dorsolateral prefrontal cortex is an established antidepressant treatment, little is known about predictors of response. The TCI measures multiple personality dimensions (harm avoidance, novelty seeking, reward dependence, persistence, self-directedness, self-transcendence, and cooperativeness), some of which have predicted response to pharmacotherapy and cognitive-behavioral therapy. A previous study suggested a possible association between self-directedness and response to rTMS in melancholic depression, although this was limited by the fact that melancholic depression is associated with a limited range of TCI profiles.
methodsNineteen patients with a major depressive episode completed the TCI before a clinical course of rTMS over the dorsolateral prefrontal cortex. Treatment response was defined as ≥50% decrease in scores on the Hamilton Rating Scale for Depression (Ham-D). Baseline scores on each TCI dimension were compared between responders and nonresponders through analysis of variance. Pearson correlations were also calculated for temperament/character scores in comparison with percentage improvement in Ham-D scores.
resultsEleven of the 19 patients responded to rTMS. T-scores for persistence were significantly higher in responders than in nonresponders (P=0.022). Linear regression revealed a correlation between persistence scores and percentage improvement in Ham-D scores.
conclusionsHigher persistence scores predicted antidepressant response to rTMS. This may be explained by rTMS-induced enhancement of cortical excitability, which has been found to be decreased in patients with high persistence. Personality assessment that includes measurement of TCI persistence may be a useful component of precision medicine initiatives in rTMS for depression.
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