Evidence map›Paper›PMID 27123491›Full record

ArticleJCI insight

Synergism of FAK and tyrosine kinase inhibition in Ph

Michelle L Churchman, Kathryn Evans, Jennifer Richmond, Alissa Robbins, Luke Jones, Irina M Shapiro, Jonathan A Pachter, David T Weaver, Peter J Houghton, Malcolm A Smith and 2 more

Open access · goldAbstract read
In one paragraph

Article in JCI insight. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Haematologica · 2024
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Multifaceted roles ofFrontiers in oncology · 2024
    Review
  13. IKAROS in Acute Leukemia: A Positive Influencer or a Mean Hater?International journal of molecular sciences · 2023
    Review
  14. Reversal ofFrontiers in oncology · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Molecular markers in ALL: Clinical implications.Best practice & research. Clinical haematology · 2020
    Review
  20. The Biology of B-Progenitor Acute Lymphoblastic Leukemia.Cold Spring Harbor perspectives in medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Michelle L ChurchmanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kathryn EvansChildren's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia.
Jennifer RichmondChildren's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia.
Alissa RobbinsChildren's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia.
Luke JonesChildren's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia.
Irina M ShapiroVerastem Inc., Needham, Massachusetts, USA.
Jonathan A PachterVerastem Inc., Needham, Massachusetts, USA.
David T WeaverVerastem Inc., Needham, Massachusetts, USA.
Peter J HoughtonGreehey Children's Cancer Research Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.
Malcolm A SmithCancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA.
Richard B LockChildren's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia.
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Verastem (United States) · USSt. Jude Children's Research Hospital · USNational Cancer Institute · USThe University of Texas Health Science Center at San Antonio · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
ANTINEOPLASTIC ALKYLGLYCEROLIPIDSR01CA042216 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI PIANTADOSI, CLAUDE · 1988 to 1990
–
NCI NIH HHS N01 CM042216NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

BCR-ABL1

Identifiers

PMID27123491
PMCPMC4844070
OpenAlexW2333877478

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.