ReviewJournal of diabetes and metabolic disorders2015
Membrane flexibility, free fatty acids, and the onset of vascular and neurological lesions in type 2 diabetes.
Review in Journal of diabetes and metabolic disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Alterations in the composition of meibomian gland secretions in patients with meibomian gland dysfunction based on Raman spectroscopy.Frontiers in medicine · 2025Article
- Identification of oleic acid as an endogenous ligand of GPR3.Cell research · 2024Article
- Thyroid Hormone Regulates the Lipid Content of Muscle Fibers, Thus Affecting Physical Exercise Performance.International journal of molecular sciences · 2023Article
- Metabolomic-Based Studies of the Intake of Virgin Olive Oil: A Comprehensive Review.Metabolites · 2023Review
- Sex hormone-binding globulin improves lipid metabolism and reduces inflammation in subcutaneous adipose tissue of metabolic syndrome-affected horses.Frontiers in molecular biosciences · 2023Article
- Free fatty acids, glucose, and insulin in type 2 diabetes mellitus.World journal of diabetes · 2022Article
- Fatty Acids: An Insight into the Pathogenesis of Neurodegenerative Diseases and Therapeutic Potential.International journal of molecular sciences · 2022Review
- Article
- Linoleic and oleic acids enhance cell migration by altering the dynamics of microtubules and the remodeling of the actin cytoskeleton at the leading edge.Scientific reports · 2021Article
- Red cell distribution width and erythrocyte osmotic stability in type 2 diabetes mellitus.Journal of cellular and molecular medicine · 2021Article
- No Evidence for Trade-Offs Between Lifespan, Fecundity, and Basal Metabolic Rate Mediated by Liver Fatty Acid Composition in Birds.Frontiers in cell and developmental biology · 2021Article
- Fatty Acid Profile of Mature Red Blood Cell Membranes and Dietary Intake as a New Approach to Characterize Children with Overweight and Obesity.Nutrients · 2020Observational
- Fundamentals about onset and progressive disease character of type 2 diabetes mellitus.World journal of diabetes · 2020Review
- Lipid-Induced Mechanisms of Metabolic Syndrome.Journal of obesity · 2020Review
- Coupling Phase Behavior of Fatty Acid Containing Membranes to Membrane Bio-Mechanics.Frontiers in cell and developmental biology · 2019Article
- The Various Roles of Fatty Acids.Molecules (Basel, Switzerland) · 2018Review
- Lipids: A Suitable Therapeutic Target in Diabetic Neuropathy?Journal of diabetes research · 2017Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Free fatty acids released from human adipose tissue contain a limited amount of non-esterified poly-cis-unsaturated fatty acids. In cases of elevated plasma free fatty acids, this condition ultimately leads to a shift from unsaturated to saturated fatty-acyl chains in membrane phospholipids. Because this shift promotes the physical attractive van der Waals interactions between phospholipid acyl chains, it increases stiffness of both erythrocyte and endothelial membranes, which causes a reduction in both insulin-independent and insulin-dependent Class 1 glucose transporters, a reduction in cell membrane functionality, and a decreased microcirculatory blood flow which results in tissue hypoxia. Against the background of these processes, we review recently published experimental phospholipid data obtained from Drosophila melanogaster and from human erythrocytes of controls and patients with type 2 diabetes, with and without retinopathy, along the way free fatty acids interfere with eye and kidney function in patients with type 2 diabetes and give rise to endoplasmic reticulum stress, reduced insulin sensitivity, and ischemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.