ArticleInternational journal of fertility & sterility
Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice.
Article in International journal of fertility & sterility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Oral supplementation with crocin (a constituent of saffron) in subjects with cigarette smoking: a clinical trial.Naunyn-Schmiedeberg's archives of pharmacology · 2024Trial
- The Therapeutic Effects ofHealth science reports · 2026Article
- Phytochemistry, Biological Activities, Molecular Mechanisms, and Toxicity of Saffron (Antioxidants (Basel, Switzerland) · 2025Review
- Letrozole and Crocin: Protecting Leydig Cells and Modulating Androgen Receptor and CYP19 Gene Expression in Busulfan-Induced Azoospermia.Animals : an open access journal from MDPI · 2025Article
- Radioprotective Effect of Resveratrol, Crocin, and Their Combination on Cytogenetic Alterations in Human Lymphocytes.Journal of biomedical physics & engineering · 2024Article
- Hypolipidemic and hepatoprotective effects of corn silk extract in nicotine-administered male mice.Gastroenterology and hepatology from bed to bench · 2024Article
- Article
- The effect of Crocin on sperm parameters disorders induced by peripheral administration of nitrosamines in male rats.Journal of medicine and life · 2022Article
- The protective effect of crocin on cisplatin-induced testicular impairment in rats.BMC urology · 2021Article
- Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats.Advances in experimental medicine and biology · 2021Article
- Protective effect of crocin on electromagnetic field-induced testicular damage and heat shock protein A2 expression in male BALB/c mice.Iranian journal of basic medical sciences · 2020Article
- The protective effect of Pentoxifylline on testopathy in male rats following Dimethyl Nitrosamine administration: An experimental study.International journal of reproductive biomedicine · 2019Article
- Effects of Crocin on Sperm Parameters and Seminiferous Tubules in Diabetic Rats.Advanced biomedical research · 2019Article
- The effect of crocin on testicular tissue and sperm parameters of mice offspring from mothers exposed to atrazine during pregnancy and lactation periods: An experimental study.International journal of reproductive biomedicine · 2018Article
- Effect of Thymoquinone on Reproductive Parameter in Morphine-treated Male Mice.Advanced biomedical research · 2018Article
- Expression Changes of Apoptotic Genes in Tissues from Mice Exposed to NicotineAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats.Avicenna journal of phytomedicineArticle
- Investigation of the neuroprotective effect of crocin against electromagnetic field-induced cerebellar damage in male Balb/c mice.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrocin, a carotenoid isolated from Crocus sativus L. (saffron), is a pharmacologically active component of saffron. Nicotine consumption can decrease fertility in males through induction of oxidative stress and DNA damage. The aim of this study is to determine the effects of crocin on reproductive parameter damages in male mice exposed to nicotine. MATERIALS AND
methodsIn this experimental study, we divided 48 mice into 8 groups (n=6 per group): control (normal saline), nicotine (2.5 mg/kg), crocin (12.5, 25 and 50 mg/kg) and crocin (12.5, 25 and 50 mg/kg)+nicotine (2.5 mg/kg). Mice received once daily intraperitoneal injections of crocin, nicotine and crocin+nicotine for 4 weeks. Sperm parameters (count, motility, and viability), testis weight, seminiferous tube diameters, testosterone, and serum nitric oxide levels were analyzed and compared.
resultsNicotine administration significantly decreased testosterone level; sperm count, viability, and motility; testis weight and seminiferous tubule diameters compared to the control group (P<0.05). However, increasing the dose of crocin in the crocin and crocin+nicotine groups significantly boosted sperm motility and viability; seminiferous tubule diameters; testis weight; and testosterone levels in all groups compared to the nicotine group (P<0.05).
conclusionCrocin improves nicotine-induced adverse effects on reproductive parameters in male mice.
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