Evidence map›Paper›PMID 27123153›Full record

ArticleInternational journal of statistics in medical research

Use of Self-Matching to Control for Stable Patient Characteristics While Addressing Time-Varying Confounding on Treatment Effect: A Case Study of Older Intensive Care Patients.

Ling Han, M A Pisani, K L B Araujo, Heather G Allore

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of statistics in medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ling HanDepartment of Internal Medicine, Program on Aging, Yale School of Medicine, New Haven, CT, USA.
M A PisaniDepartment of Internal Medicine, Program on Aging, Yale School of Medicine, New Haven, CT, USA; Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
K L B AraujoDepartment of Internal Medicine, Program on Aging, Yale School of Medicine, New Haven, CT, USA.
Heather G AlloreDepartment of Internal Medicine, Program on Aging, Yale School of Medicine, New Haven, CT, USA; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
Yale University · US

Funding

Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
Individualized Absolute Risk calculator For Persons With Multiple Chronic ConditionsR01AG047891 · NIA · YALE UNIVERSITY · PI ALLORE, HEATHER GWYNN · 2015 to 2017
$990k
Impact of Psychoactive Drugs on Delirium in ICU PatientsK23AG023023 · NIA · YALE UNIVERSITY · PI PISANI, MARGARET A · 2004 to 2008
$764k
Health Outcome Effects of Common Medications in Elders with Multiple ConditionsR21AG045148 · NIA · YALE UNIVERSITY · PI ALLORE, HEATHER GWYNN, TINETTI, MARY E · 2013 to 2014
$458k
Feasibility of Measuring Sleep in a Critical Care EnvironmentR21NR011066 · NINR · YALE UNIVERSITY · PI PISANI, MARGARET A · 2009 to 2010
$439k
NIA NIH HHS K23 AG023023NIA NIH HHS P30 AG021342NIA NIH HHS R01 AG047891NIA NIH HHS R21 AG045148NINR NIH HHS R21 NR011066
6 · The paper itself

Abstract

Exposure-crossover design offers a non-experimental option to control for stable baseline confounding through self-matching while examining causal effect of an exposure on an acute outcome. This study extends this approach to longitudinal data with repeated measures of exposure and outcome using data from a cohort of 340 older medical patients in an intensive care unit (ICU). The analytic sample included 92 patients who received ≥1 dose of haloperidol, an antipsychotic medication often used for patients with delirium. Exposure-crossover design was implemented by sampling the 3-day time segments prior (

Indexed as

causal effectsconfoundingExposure-crossover designgeneralized estimating equationself-matching

Identifiers

PMID27123153
PMCPMC4844076
OpenAlexW2269782984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.