Evidence map›Paper›PMID 27123045›Full record

ArticleMolecular cytogenetics2016

Chromosomes in a genome-wise order: evidence for metaphase architecture.

Anja Weise, Samarth Bhatt, Katja Piaszinski, Nadezda Kosyakova, Xiaobo Fan, Annelore Altendorf-Hofmann, Alongklod Tanomtong, Arunrat Chaveerach, Marcelo Bello de Cioffi, Edivaldo de Oliveira and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cytogenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Mitotic Antipairing of Homologous Chromosomes.Results and problems in cell differentiation · 2022
    Article
  4. Article
  5. Article
  6. Leukocyte Nucleus Reveals a Linear Order of Chromosomes Separated in Two Parental Genomes That Favors the Process of Gene Activation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019
    Article
  7. From Human Cytogenetics to Human Chromosomics.International journal of molecular sciences · 2019
    Review
  8. Review
  9. Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anja WeiseInstitute of Human Genetics, Jena University Hospital, Postfach, 07740, Jena, Germany.
Samarth BhattInstitute of Human Genetics, Jena University Hospital, Postfach, 07740, Jena, Germany.
Katja PiaszinskiInstitute of Human Genetics, Jena University Hospital, Postfach, 07740, Jena, Germany.
Nadezda KosyakovaInstitute of Human Genetics, Jena University Hospital, Postfach, 07740, Jena, Germany.
Xiaobo FanInstitute of Human Genetics, Jena University Hospital, Postfach, 07740, Jena, Germany.
Annelore Altendorf-HofmannDepartment of General, Visceral und Vascular Surgery, Jena University Hospital, Kochstr. 2, Jena, 07743 Germany.
Alongklod TanomtongDepartment of Biology, Faculty of Science, Khon Kaen University, 123 Moo 16 Mittapap Rd, Khon Kaen, Muang District 40002 Thailand.
Arunrat ChaveerachDepartment of Biology, Faculty of Science, Khon Kaen University, 123 Moo 16 Mittapap Rd, Khon Kaen, Muang District 40002 Thailand.
Marcelo Bello de CioffiDepartamento de Genética e Evolução, Universidade Federal de São Carlos, São Carlos, SP Brazil.
Edivaldo de OliveiraInstituto Evandro Chagas, Seção de Meio Ambiente, Laboratório de Cultura de Tecidos e Citogenética, Ananindeua, PA Brazil.
Joachim-U WaltherInstituto Evandro Chagas, Seção de Meio Ambiente, Laboratório de Cultura de Tecidos e Citogenética, Ananindeua, PA Brazil.
Thomas LiehrInstitute of Human Genetics, Jena University Hospital, Postfach, 07740, Jena, Germany.
Jyoti P ChaudhuriInstitute of Human Genetics, Jena University Hospital, Postfach, 07740, Jena, Germany ; Kinderklinik, Ludwig Maximillians Universität, 80337 Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOne fundamental finding of the last decade is that, besides the primary DNA sequence information there are several epigenetic "information-layers" like DNA-and histone modifications, chromatin packaging and, last but not least, the position of genes in the nucleus.

resultsWe postulate that the functional genomic architecture is not restricted to the interphase of the cell cycle but can also be observed in the metaphase stage, when chromosomes are most condensed and microscopically visible. If so, it offers the unique opportunity to directly analyze the functional aspects of genomic architecture in different cells, species and diseases. Another aspect not directly accessible by molecular techniques is the genome merged from two different haploid parental genomes represented by the homologous chromosome sets. Our results show that there is not only a well-known and defined nuclear architecture in interphase but also in metaphase leading to a bilateral organization of the two haploid sets of chromosomes. Moreover, evidence is provided for the parental origin of the haploid grouping.

conclusionsFrom our findings we postulate an additional epigenetic information layer within the genome including the organization of homologous chromosomes and their parental origin which may now substantially change the landscape of genetics.

Indexed as

ChromosomesGenome architectureHaploid groupingMetaphaseParental origin

Identifiers

PMID27123045
PMCPMC4847357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.