Evidence map›Paper›PMID 27122918›Full record

ArticleActa Cardiologica Sinica2015

Lack of Association between High-Density Lipoprotein Cholesterol and Angiographic Coronary Lesion Severity in Chinese Patients with Low Background Low-Density Lipoprotein Cholesterol.

Chieh-Shou Su, Kuan-Ju Chen, Wayne Huey-Herng Sheu, Ya-Ling Yang, Tsun-Jui Liu, Wei-Chun Chang, Kuo-Yang Wang, Wen-Lieng Lee

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Article in Acta Cardiologica Sinica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chieh-Shou SuCardiovascular Center, Taichung Veterans General Hospital, Taichun; ; Institute of Clinical Medicine, Cardiovascular Research Center, and Department of Medicine, National Yang Ming University School of Medicine, Taipei;
Kuan-Ju ChenCardiovascular Center, Taichung Veterans General Hospital, Taichun;
Wayne Huey-Herng SheuDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Taichung Veterans General Hospital; ; Department of Medicine, Chung Shan Medical University; ; Institute of Medical Technology, National Chung Hsing University, Taichung; ; College of Medicine, National Yang Ming University School of Medicine, Taipei;
Ya-Ling YangDepartment of Anesthesiology, Taichung Veterans General Hospital;
Tsun-Jui LiuCardiovascular Center, Taichung Veterans General Hospital, Taichun; ; Institute of Clinical Medicine, Cardiovascular Research Center, and Department of Medicine, National Yang Ming University School of Medicine, Taipei;
Wei-Chun ChangCardiovascular Center, Taichung Veterans General Hospital, Taichun; ; Institute of Clinical Medicine, Cardiovascular Research Center, and Department of Medicine, National Yang Ming University School of Medicine, Taipei;
Kuo-Yang WangCardiovascular Center, Taichung Veterans General Hospital, Taichun; ; Department of Medicine, Chung Shan Medical University; ; Department of Medicine, China Medical University, Taichung Taiwan.
Wen-Lieng LeeCardiovascular Center, Taichung Veterans General Hospital, Taichun; ; Institute of Clinical Medicine, Cardiovascular Research Center, and Department of Medicine, National Yang Ming University School of Medicine, Taipei;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe atheroprotective role of high-density lipoprotein (HDL-C) particles as measured by HDL-C level in coronary arterial disease (CAD) remains unsettled. The aim of our study was to ascertain whether HDL-C was associated with the development and severity of coronary artery disease in Chinese patients who underwent coronary angiogram with low background Low-density lipoprotein (LDL-C) levels, which has not been previously investigated.

methodsBetween March 1995 and May 2000, 566 consecutive patients (408 males, 66.7 ± 11.3 years of age) with background LDL-C less than 100 mg/dl who underwent coronary artery angiography at our cath lab for suspected CAD were retrospectively recruited into the study. The severity of coronary lesions was measured by conventional coronary angiography and modified Gensini scores.

resultsIn those subjects with significant coronary lesions, there were more males and conventional CAD risk factors of diabetes mellitus, smoking, and chronic renal disease. They were also older compared to those in the control group. However, total cholesterol, LDL-C, HDL-C, triglyceride levels and use of statins were similar in both groups. In those subjects with significant coronary lesions, there was no difference in conventional coronary lesion severity or modified Gensini score between the quartered HDL-C subgroups. Furthermore, there was no significant correlation between serum HDL-C level and modified Gensini scores. In linear regression analysis, HDL-C was not an independent predictor for modified Gensini scores. Furthermore, HDL-C was also not an independent risk factor for the presence of significant coronary lesions in low LDL-C patients in logistic regression analysis.

conclusionsIn Chinese patients with low background LDL-C, serum HDL-C was not associated with development of CAD or lesion severity in patients with suspected CAD. Therefore, HDL-C did not appear to be atheroprotective in these patients. KEY WORDS: Coronary artery disease; Gensini score; High-density lipoprotein cholesterol.

Identifiers

PMID27122918
PMCPMC4804978

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.