LDL Cholesterol Goal Attainment in Hypercholesterolemia: CEPHEUS Indonesian Survey.

backgroundSeveral studies have shown that lipid-lowering therapy to address hypercholesterolemia is generally inadequate because the target cholesterol goal is not achieved. Our study reviews the cholesterol goal attainment among patients receiving lipid lowering therapy in Indonesian hypercholesterolemic patients.

methodsThis surveywas part of the Pan-Asian CEPHEUS (CEntralized Pan-Asian survey on tHE Under-treatment of hypercholeSterolemia) study, involving hypercholesterolemic patients ≥ 18 years of age, who were on lipid- lowering treatment for ≥ 3 months. Lipid concentrations were measured, demographic and other clinically relevant information were collected. Definitions and criteria set by the updated 2004 National Cholesterol Education Program - Adult Treatment Program III was applied.

resultsIn this survey, 149 physicians enrolled 979 patients, of whom only 834 were included in the final analysis. The mean age was 56.5 years, 53.5% male, and 82.3% were on statin monotherapy. The LDL-C goal attainment rate amongst Indonesians (31.3%)was belowthat of the overall Asian rate (49.1%). The lowest attainment (12.1%)was found in patients with a therapeutic target < 70 mg/dL. Additionally, the goal attainment rate in patients with metabolic syndrome (28%) was significantly lower than in patients without metabolic syndrome (37.5%, p = 0.006). Goal attainment was inversely related to cardiovascular risk and baseline LDL-C (p < 0.001). It was also noted that approximately 65.1% of patients believed he/she could miss a dosage without affecting his/her blood cholesterol concentration.

conclusionsHigh proportions of Indonesian hypercholesterolemic patients on lipid-lowering drug are not at the recommended LDL-C levels, and remain at risk for cardiovascular disease. KEY WORDS: Cardiovascular disease; Dyslipidemia; Hypercholesterolemia; Indonesian; LDL cholesterol.