ArticleInternational journal of biotechnology
Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective.
Article in International journal of biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Deep Learning Image Analysis of High-Throughput Toxicology Assay Images.SLAS discovery : advancing life sciences R & D · 2022Article
- The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.Chemical research in toxicology · 2021Review
- An Optimized Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples.Metabolites · 2020Article
- High-Content Image-Based Single-Cell Phenotypic Analysis for the Testicular Toxicity Prediction Induced by Bisphenol A and Its Analogs Bisphenol S, Bisphenol AF, and Tetrabromobisphenol A in a Three-Dimensional Testicular Cell Co-culture Model.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Utility of Extrapolating Human S1500+ Genes to the Whole Transcriptome: Tunicamycin Case Study.Bioinformatics and biology insights · 2020Article
- Next generation sequencing data for use in risk assessment.Current opinion in toxicology · 2019Article
- Progress in data interoperability to support computational toxicology and chemical safety evaluation.Toxicology and applied pharmacology · 2019Review
- Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics.Zebrafish · 2019Article
- The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Advancing Computational Toxicology in the Big Data Era by Artificial Intelligence: Data-Driven and Mechanism-Driven Modeling for Chemical Toxicity.Chemical research in toxicology · 2019Review
- Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.Applied in vitro toxicology · 2019Article
- Toxicogenomics: A 2020 Vision.Trends in pharmacological sciences · 2019Review
- Ontology-based semantic mapping of chemical toxicities.Toxicology · 2019Article
- Optimization of a Deep-Learning Method Based on the Classification of Images Generated by Parameterized Deep Snap a Novel Molecular-Image-Input Technique for Quantitative Structure-Activity Relationship (QSAR) Analysis.Frontiers in bioengineering and biotechnology · 2019Article
- Article
- Novel application of normalized pointwise mutual information (NPMI) to mine biomedical literature for gene sets associated with disease: use case in breast carcinogenesis.Computational toxicology (Amsterdam, Netherlands) · 2018Article
- Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126.Archives of toxicology · 2018Article
- BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening.Computational toxicology (Amsterdam, Netherlands) · 2018Article
- Opportunities and challenges in phenotypic drug discovery: an industry perspective.Nature reviews. Drug discovery · 2017Review
- A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics.Frontiers in genetics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Humans are exposed to thousands of chemicals with inadequate toxicological data. Advances in computational toxicology, robotic high throughput screening (HTS), and genome-wide expression have been integrated into the Tox21 program to better predict the toxicological effects of chemicals. Tox21 is a collaboration among US government agencies initiated in 2008 that aims to shift chemical hazard assessment from traditional animal toxicology to target-specific, mechanism-based, biological observations using
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.