Evidence map›Paper›PMID 27122592›Full record

ArticleThe Journal of infectious diseases2016

Host Polymorphisms in TLR9 and IL10 Are Associated With the Outcomes of Experimental Haemophilus ducreyi Infection in Human Volunteers.

Martin Singer, Wei Li, Servaas A Morré, Sander Ouburg, Stanley M Spinola

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Molecular pathogenesis ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  2. Article
  3. Interactions of the Skin PathogenFrontiers in immunology · 2020
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Martin SingerLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam.
Wei LiDepartment of Microbiology and Immunology.
Servaas A MorréLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam Institute for Public Health Genomics, Department of Genetics and Cell Biology, School for Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands.
Sander OuburgLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam.
Stanley M SpinolaDepartment of Microbiology and Immunology Departments of Medicine Pathology and Laboratory Medicine Center for Immunobiology, Indiana University School of Medicine, Indiana University, Indianapolis.
Amsterdam UMC Location VUmc · NLIndiana University – Purdue University Indianapolis · USMaastricht University · NL

Funding

VIRAL DETERMINANTS OF HSV DISEASE IN MICEU19AI031494 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SPINOLA, STANLEY M. · 1995 to 2009
$13.6M
PATHOGENESIS OF HAEMOPHILUS DUCREYI INFECTIONSR01AI027863 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SPINOLA, STANLEY M. · 1995 to 2013
$3.8M
Human Immune Response to Haemophilus Ducreyi InfectionR01AI059384 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SPINOLA, STANLEY M. · 2007 to 2011
$1.8M
NIAID NIH HHS R01 AI027863NIAID NIH HHS R01 AI059384NIAID NIH HHS U19 AI031494
6 · The paper itself

Abstract

backgroundIn humans inoculated with Haemophilus ducreyi, there are host effects on the possible clinical outcomes-pustule formation versus spontaneous resolution of infection. However, the immunogenetic factors that influence these outcomes are unknown. Here we examined the role of 14 single-nucleotide polymorphisms (SNPs) in 7 selected pathogen-recognition pathways and cytokine genes on the gradated outcomes of experimental infection.

methodsDNAs from 105 volunteers infected with H. ducreyi at 3 sites were genotyped for SNPs, using real-time polymerase chain reaction. The participants were classified into 2 cohorts, by race, and into 4 groups, based on whether they formed 0, 1, 2, or 3 pustules. χ(2) tests for trend and logistic regression analyses were performed on the data.

resultsIn European Americans, the most significant findings were a protective association of the TLR9 +2848 GG genotype and a risk-enhancing association of the TLR9 TA haplotype with pustule formation; logistic regression showed a trend toward protection for the TLR9 +2848 GG genotype. In African Americans, logistic regression showed a protective effect for the IL10 -2849 AA genotype and a risk-enhancing effect for the IL10 AAC haplotype.

conclusionsVariations in TLR9 and IL10 are associated with the outcome of H. ducreyi infection.

Indexed as

Polymorphism, Single NucleotideAdultBlack or African AmericanChancroidCohort StudiesFemaleGenetic Association StudiesGenotypeHaemophilus ducreyiHealthy VolunteersHumansInterleukin-10MaleMiddle AgedReal-Time Polymerase Chain ReactionToll-Like Receptor 9IL10 protein, humanInterleukin-10TLR9 protein, humanToll-Like Receptor 9chancroidHaemophilus ducreyihumansimmunogeneticsinnate immunityskin ulcers

Identifiers

PMID27122592
PMCPMC4936646
OpenAlexW2343332113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.