ArticleProceedings. Biological sciences2016
Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 87 citations in OpenAlex.
- Coral color morphs exhibit distinct microbial and proteomic profiles linked to stress and immune mechanisms in a changing ocean.Microbiome · 2026Article
- Nitrate Aggravates While Ammonium Mitigates Thermal Bleaching in Corals through Divergent Lipid-Mediated Pathways and Stress Response.Environmental science & technology · 2026Article
- Species-specific metabolomic profiles of coral reef coralline algae and their influence on the larval settlement of corals and crown-of-thorns starfish.Scientific reports · 2025Article
- Contact- and Water-Mediated Interactions With an Allelopathic Macroalga Drive Distinct Coral Microbiome and Metabolome.Environmental microbiology · 2025Article
- Intergenerational metabolomic signatures of bleaching resistance in corals.Nature communications · 2025Article
- Exploring interspecific interaction variability in microbiota: A review.Engineering microbiology · 2024Review
- Benzoyl Chloride Derivatization Advances the Quantification of Dissolved Polar Metabolites on Coral Reefs.Journal of proteome research · 2024Article
- Article
- Microbiomes and metabolomes of dominant coral reef primary producers illustrate a potential role for immunolipids in marine symbioses.Communications biology · 2023Article
- The coral microbiome: towards an understanding of the molecular mechanisms of coral-microbiota interactions.FEMS microbiology reviews · 2023Article
- The community ecology perspective of omics data.Microbiome · 2022Article
- Metabolomics Characterization of Scleractinia Corals with Different Life-History Strategies: A Case Study aboutMetabolites · 2022Article
- Disease resistance in coral is mediated by distinct adaptive and plastic gene expression profiles.Science advances · 2022Article
- Metabolomics on the study of marine organisms.Metabolomics : Official journal of the Metabolomic Society · 2022Review
- Comparative metabolomic analysis reveals shared and unique chemical interactions in sponge holobionts.Microbiome · 2022Article
- Coral larval settlement preferences linked to crustose coralline algae with distinct chemical and microbial signatures.Scientific reports · 2021Article
- Intraspecific variation in polar and nonpolar metabolite profiles of a threatened Caribbean coral.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Metabolomic signatures of coral bleaching history.Nature ecology & evolution · 2021Article
- How Do the Players Play? A Post-Genomic Analysis Paradigm to Understand Aquatic Ecosystem Processes.Frontiers in molecular biosciences · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Holobionts are assemblages of microbial symbionts and their macrobial host. As extant representatives of some of the oldest macro-organisms, corals and algae are important for understanding how holobionts develop and interact with one another. Using untargeted metabolomics, we show that non-self interactions altered the coral metabolome more than self-interactions (i.e. different or same genus, respectively). Platelet activating factor (PAF) and Lyso-PAF, central inflammatory modulators in mammals, were major lipid components of the coral holobionts. When corals were damaged during competitive interactions with algae, PAF increased along with expression of the gene encoding Lyso-PAF acetyltransferase; the protein responsible for converting Lyso-PAF to PAF. This shows that self and non-self recognition among some of the oldest extant holobionts involve bioactive lipids identical to those in highly derived taxa like humans. This further strengthens the hypothesis that major players of the immune response evolved during the pre-Cambrian.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.