ArticleProceedings of the National Academy of Sciences of the United States of America2016
Eyespot-dependent determination of the phototactic sign in Chlamydomonas reinhardtii.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
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- Light-dependent processes in algae across scales: from cellular physiology to ecological organization.Plant physiology · 2026Review
- Theory of cell body lensing and phototaxis sign reversal in "eyeless" mutants of Chlamydomonas.Physical review. E · 2026Article
- Motilitometer: A compact modular microscope for motility and photoresponse analysis of microorganisms.HardwareX · 2026Article
- Algal optics.Physical review. E · 2026Article
- Chlamylipo, aBiophysics and physicobiology · 2026Article
- Interactions Between Active Matters and Endogenous Fields.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Shear-induced ciliary autotomy mediated by a TRP channel and a voltage-dependent calcium channel.iScience · 2025Article
- Micro/Nano-Motors for Enhanced Tumor Diagnosis and Therapy.International journal of molecular sciences · 2025Review
- Microalgae-driven microrobots: revolutionizing drug delivery and targeted therapy in biopharmaceuticals.Advanced biotechnology · 2025Review
- Intermediate light adaptation induces oscillatory phototaxis switching and pattern formation inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Bestrophin-like protein 4 is involved in photosynthetic acclimation to light fluctuations in Chlamydomonas.Plant physiology · 2024Article
- Protofilament-specific nanopatterns of tubulin post-translational modifications regulate the mechanics of ciliary beating.Current biology : CB · 2024Article
- Implicating the red body of Nannochloropsis in forming the recalcitrant cell wall polymer algaenan.Nature communications · 2024Article
- Biohybrid Microalgae Robots: Design, Fabrication, Materials, and Applications.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Aberrant light sensing and motility in the green algaPlant signaling & behavior · 2023Article
- Illuminating the diversity of carotenoids in microalgal eyespots and phototaxis.Plant signaling & behavior · 2023Review
- Photobehaviours guided by simple photoreceptor systems.Animal cognition · 2023Review
- Mechanoresponses mediated by the TRP11 channel in cilia ofiScience · 2023Article
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13 authors.
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Abstract
The biflagellate green alga Chlamydomonas reinhardtii exhibits both positive and negative phototaxis to inhabit areas with proper light conditions. It has been shown that treatment of cells with reactive oxygen species (ROS) reagents biases the phototactic sign to positive, whereas that with ROS scavengers biases it to negative. Taking advantage of this property, we isolated a mutant, lts1-211, which displays a reduction-oxidation (redox) dependent phototactic sign opposite to that of the wild type. This mutant has a single amino acid substitution in phytoene synthase, an enzyme that functions in the carotenoid-biosynthesis pathway. The eyespot contains large amounts of carotenoids and is crucial for phototaxis. Most lts1-211 cells have no detectable eyespot and reduced carotenoid levels. Interestingly, the reversed phototactic-sign phenotype of lts1-211 is shared by other eyespot-less mutants. In addition, we directly showed that the cell body acts as a convex lens. The lens effect of the cell body condenses the light coming from the rear onto the photoreceptor in the absence of carotenoid layers, which can account for the reversed-phototactic-sign phenotype of the mutants. These results suggest that light-shielding property of the eyespot is essential for determination of phototactic sign.
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