ArticleDevelopment (Cambridge, England)2016
Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by Dact1/2.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Genetic requirement ofeLife · 2024Article
- Genetic requirement ofbioRxiv : the preprint server for biology · 2024Article
- Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications.Frontiers in cell and developmental biology · 2024Review
- The Tumor SuppressorJournal of developmental biology · 2023Article
- RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification.eLife · 2022Article
- Time to go: neural crest cell epithelial-to-mesenchymal transition.Development (Cambridge, England) · 2022Review
- PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.Stem cell reports · 2021Article
- Stationed or Relocating: The Seesawing EMT/MET Determinants from Embryonic Development to Cancer Metastasis.Biomedicines · 2021Review
- Dbnl and β-catenin promote pro-N-cadherin processing to maintain apico-basal polarity.The Journal of cell biology · 2021Article
- Transcriptomic Identification of Draxin-Responsive Targets During Cranial Neural Crest EMT.Frontiers in physiology · 2021Article
- Single-Cell Multiomic Approaches Reveal Diverse Labeling of the Nervous System by Common Cre-Drivers.Frontiers in cellular neuroscience · 2021Article
- Insights into the genetic architecture of the human face.Nature genetics · 2021Article
- A Zic2-regulated switch in a noncanonical Wnt/βcatenin pathway is essential for the formation of bilateral circuits.Science advances · 2020Article
- Epithelial-to-mesenchymal transition and different migration strategies as viewed from the neural crest.Current opinion in cell biology · 2020Review
- Bimodal function of chromatin remodelereLife · 2020Article
- The transcription factor Hypermethylated in Cancer 1 (Hic1) regulates neural crest migration via interaction with Wnt signaling.Developmental biology · 2020Article
- A genome-wide assessment of the ancestral neural crest gene regulatory network.Nature communications · 2019Article
- Review
- miR-124 promotes proliferation and neural differentiation of neural stem cells through targeting DACT1 and activating Wnt/β-catenin pathways.Molecular and cellular biochemistry · 2018Article
- Draxin acts as a molecular rheostat of canonical Wnt signaling to control cranial neural crest EMT.The Journal of cell biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Delamination of neural crest (NC) cells is a bona fide physiological model of epithelial-to-mesenchymal transition (EMT), a process that is influenced by Wnt/β-catenin signalling. Using two in vivo models, we show that Wnt/β-catenin signalling is transiently inhibited at the time of NC delamination. In attempting to define the mechanism underlying this inhibition, we found that the scaffold proteins Dact1 and Dact2, which are expressed in pre-migratory NC cells, are required for NC delamination in Xenopus and chick embryos, whereas they do not affect the motile properties of migratory NC cells. Dact1/2 inhibit Wnt/β-catenin signalling upstream of the transcriptional activity of T cell factor (TCF), which is required for EMT to proceed. Dact1/2 regulate the subcellular distribution of β-catenin, preventing β-catenin from acting as a transcriptional co-activator to TCF, yet without affecting its stability. Together, these data identify a novel yet important regulatory element that inhibits β-catenin signalling, which then affects NC delamination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.