Evidence map›Paper›PMID 27122131›Full record

ArticleBMC pediatrics2016

Gestational age, mode of birth and breastmilk feeding all influence acute early childhood gastroenteritis: a record-linkage cohort study.

Jason P Bentley, Judy M Simpson, Jenny R Bowen, Jonathan M Morris, Christine L Roberts, Natasha Nassar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

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  9. Beneficial Effects ofFrontiers in pediatrics · 2022
    Article
  10. Persistence of G10P[11] neonatal rotavirus infections in southern India.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jason P BentleyClinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia. jben9630@uni.sydney.edu.au.
Judy M SimpsonSydney School of Public Health, University of Sydney, Sydney, NSW, Australia.
Jenny R BowenClinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia.
Jonathan M MorrisClinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia.
Christine L RobertsClinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia.
Natasha NassarClinical and Population Perinatal Health Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia.
University of Sydney · AURoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute gastroenteritis (AGE) is a leading cause of infectious morbidity in childhood. Clinical studies have implicated caesarean section, early birth and formula feeding in modifying normal gut microbiota development and immune system homeostasis in early life. Rates of early birth and cesarean delivery are also increasing worldwide. This study aimed to investigate the independent and combined associations of the mode and timing of birth and breastmilk feeding with AGE hospitalisations in early childhood.

methodsPopulation-based record-linkage study of 893,360 singleton livebirths of at least 33 weeks gestation without major congenital conditions born in hospital, New South Wales, Australia, 2001-2011. Using age at first AGE hospital admission, Cox-regression was used to estimate the associations for gestational age, vaginal birth or caesarean delivery by labour onset and formula-only feeding while adjusting for confounders.

resultsThere were 41,274 (4.6 %) children admitted to hospital at least once for AGE and the median age at first admission was 1.4 years. Risk of AGE admission increased with decreasing gestational age (37-38 weeks: 15 % increased risk, 33-36 weeks: 25 %), caesarean section (20 %), planned birth (17 %) and formula-only feeding (18 %). The rate of AGE admission was highest for children who were born preterm by modes of birth other than vaginal birth following the spontaneous onset of labour and who received formula-only at discharge from birth care (62-78 %).

conclusionsVaginal birth following spontaneous onset of labour at 39+ weeks gestation with any breastfeeding minimised the risk of gastroenteritis hospitalisation in early childhood. Given increasing trends in early planned birth and caesarean section worldwide, these results provide important information about the impact obstetric interventions may have on the development of the infant gut microbiota and immunity.

Indexed as

Breast FeedingPremature BirthAcute DiseaseCesarean SectionChildChild, PreschoolCohort StudiesDelivery, ObstetricFemaleGastroenteritisGestational AgeHospitalizationHumansInfantInfant FormulaInfant, NewbornAcute gastroenteritisBreastfeedingCaesarean sectionChildEarly term birthHealthy start to life

Identifiers

PMID27122131
PMCPMC4847338
OpenAlexW2344621798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.