ArticleNature communications2016
Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
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- Harnessing human genetics and stem cells for precision cardiovascular medicine.Cell genomics · 2024Review
- Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs.Npj viruses · 2023Article
- Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells.Cell death discovery · 2022Article
- Long noncoding RNA NEAT1 promotes cardiac fibrosis in heart failure through increased recruitment of EZH2 to the Smad7 promoter region.Journal of translational medicine · 2022Article
- SH3-Binding Glutamic Acid Rich-Deficiency Augments Apoptosis in Neonatal Rat Cardiomyocytes.International journal of molecular sciences · 2021Article
- Risk Compounds, Preclinical Toxicity Evaluation, and Potential Mechanisms of Chinese Materia Medica-Induced Cardiotoxicity.Frontiers in pharmacology · 2021Review
- Presynaptic L-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Metformin Shortens Prolonged QT Interval in Diabetic Mice by Inhibiting L-Type Calcium Current: A Possible Therapeutic Approach.Frontiers in pharmacology · 2020Article
- Targeting Calcium Homeostasis in Myocardial Ischemia/Reperfusion Injury: An Overview of Regulatory Mechanisms and Therapeutic Reagents.Frontiers in pharmacology · 2020Review
- Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.EMBO molecular medicine · 2019Article
- Augmentation of myocardial INature communications · 2019Article
- STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- STRIP2 Is Indispensable for the Onset of Embryonic Stem Cell Differentiation.Molecular therapy. Methods & clinical development · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel. Knockdown of Myoscape in cardiomyocytes decreases calcium transients associated with smaller Ca(2+) amplitudes and a lower diastolic Ca(2+) content. Likewise, L-type calcium channel currents are significantly diminished on Myoscape ablation, and downregulation of Myoscape significantly reduces contractility of cardiomyocytes. Conversely, overexpression of Myoscape increases global Ca(2+) transients and enhances L-type Ca(2+) channel currents, and is sufficient to restore decreased currents in failing cardiomyocytes. In vivo, both Myoscape-depleted morphant zebrafish and Myoscape knockout (KO) mice display impairment of cardiac function progressing to advanced heart failure. Mechanistically, Myoscape-deficient mice show reduced L-type Ca(2+)currents, cell capacity and calcium current densities as a result of diminished LTCC surface expression. Finally, Myoscape expression is reduced in hearts from patients suffering of terminal heart failure, implying a role in human disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.