Evidence map›Paper›PMID 27122004›Full record

ArticleInternational journal of geriatric psychiatry2017

Genetic and environmental factors associated with delirium severity in older adults with dementia.

Lauren Massimo, Elizabeth Munoz, Nikki Hill, Jacqueline Mogle, Paula Mulhall, Corey T McMillan, Linda Clare, David Vandenbergh, Donna Fick, Ann Kolanowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of geriatric psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. The complex interaction of genetics and delirium: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2021
    Pooled it
  3. Article
  4. Article
  5. Article
  6. ICU Delirium in Cardiac Patients.Methodist DeBakey cardiovascular journal · 2023
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Lauren MassimoCollege of Nursing, The Pennsylvania State University, University Park, PA, USA.
Elizabeth MunozSchool of Psychology, University of California, Riverside, CA, USA.
Nikki HillCollege of Nursing, The Pennsylvania State University, University Park, PA, USA.
Jacqueline MogleCollege of Nursing, The Pennsylvania State University, University Park, PA, USA.
Paula MulhallCollege of Nursing, The Pennsylvania State University, University Park, PA, USA.
Corey T McMillanFrontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA, USA.
Linda ClareDepartment of Psychology, University of Exeter, Exeter, UK.
David VandenberghDepartment of Biobehavioral Health, Huck Institute for the Neurosciences, Molecular and Cellular Integrative Biosciences Program, The Pennsylvania State University, University Park, PA, USA.
Donna FickCollege of Nursing, The Pennsylvania State University, University Park, PA, USA.
Ann KolanowskiCollege of Nursing, The Pennsylvania State University, University Park, PA, USA.
Pennsylvania State University · USUniversity of Pennsylvania · USUniversity of California, Riverside · USUniversity of Exeter · GB

Funding

Transgenic Mouse Models of Tau PathologiesP01AG017586 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LEE, VIRGINIA M · 2000 to 2021
$37.3M
RESERVE for Delirium Superimposed on Dementia (DSD)R01NR012242 · NINR · PENNSYLVANIA STATE UNIVERSITY, THE · PI FICK, DONNA MARIE, KOLANOWSKI, ANN M · 2010 to 2014
$2.1M
Multimodal Biomarkers in Frontotemporal Lobar DegenerationK01AG043503 · NIA · UNIVERSITY OF PENNSYLVANIA · PI MCMILLAN, COREY T · 2013 to 2017
$642k
Cognitive and Neural Moderators of Longitudinal Decline in Frontotemporal DegenerationK99AG056054 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI MASSIMO, LAUREN M · 2016 to 2017
$192k
The Neural Basis of Apathy in Frontotemporal Degeneration: A Longitudinal StudyF32NR014777 · NINR · PENNSYLVANIA STATE UNIVERSITY, THE · PI MASSIMO, LAUREN M · 2013 to 2016
$144k
NIA NIH HHS K01 AG043503NIA NIH HHS K99 AG056054NIA NIH HHS P01 AG017586NINR NIH HHS F32 NR014777NINR NIH HHS R01 NR012242
6 · The paper itself

Abstract

objectiveTo determine (1) whether delirium severity was associated with Apolipoprotein E (APOE) genotype status and occupational complexity, a measure of cognitive reserve, in individuals with delirium superimposed on dementia; and (2) whether decline in delirium severity was associated with these same factors over a post-acute care (PAC) stay.

methodsControl group data (n = 142) from a completed randomized clinical trial were used to address the aims of the study. Delirium severity was calculated by combining items from the Confusion Assessment Method and the Montreal Cognitive Assessment. APOE ε4 carriers versus non-carriers were considered. Occupational complexity, a measure of cognitive reserve, was derived from the Lifetime of Experiences Questionnaire. Covariates examined included age, gender, education, Clinical Dementia Rating Scale, and the Charlson comorbidity score. Data were nested (i.e., days nested within persons) and analyzed using multilevel models.

resultsThe presence of an APOE ε4 allele and higher Clinical Dementia Rating Scale were associated with greater delirium severity at baseline. The presence of an APOE ε4 allele was also associated with greater delirium severity averaged across the PAC stay. Occupational complexity was not associated with baseline delirium severity or average daily delirium severity; however, individuals with low occupational complexity showed a significant decreased in delirium severity during the course of their PAC stay.

conclusionsIndividual differences, including genetic factors and level of cognitive reserve, contribute to the severity of delirium in older adults with dementia. Copyright © 2016 John Wiley & Sons, Ltd.

Indexed as

Gene-Environment InteractionAgedAged, 80 and overAllelesApolipoprotein E4Cognitive ReserveDeliriumDementiaFemaleGenotypeHumansMalePsychiatric Status Rating ScalesRisk FactorsSeverity of Illness IndexApolipoprotein E4APOEcognitive reservedeliriumdementia

Identifiers

PMID27122004
PMCPMC5083230
OpenAlexW2345947800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.