Evidence map›Paper›PMID 27121707›Full record

ReviewCritical care (London, England)2016

Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure.

Oriol Roca, Gonzalo Hernández, Salvador Díaz-Lobato, José M Carratalá, Rosa M Gutiérrez, Joan R Masclans, Spanish Multidisciplinary Group of High Flow Supportive Therapy in Adults (HiSpaFlow)

4 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 84 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 9 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03460119 completednot on this map

Use of High-Flow Nasal Cannula for Acute Respiratory Failure in the Emergency Department

TypeobservationalSponsorHospital Italiano de Buenos AiresRan2015 to 2017Enrolled43ConditionsAcute Respiratory FailureArmsHigh Flow Nasal Cannula Oxygen
NCT04782817 nacompletednot on this mapstarted 2021, after this paper: background citation

Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients With High-Flow Nasal Cannula

TypeinterventionalSponsorVanderbilt University Medical CenterRan2021 to 2026Enrolled3,568ConditionsIntubation, Cardiovascular Surgical ProcedureArmsRecommendation for high flow nasal cannula oxygen therapy order set, Provider choice standard care order set
NCT05904652 nacompletednot on this mapstarted 2023, after this paper: background citation

A Randomised, Feasibility Trial of Simultaneous Application of Flow at Extubation (SAFEx) in Patients Requiring Intubation and Ventilation for the Management of Acute Respiratory Failure

TypeinterventionalSponsorNHS Greater Glasgow and ClydeRan2023 to 2024Enrolled2ConditionsRespiratory InsufficiencyArmsFisher and Paykel "HealthCare Airvo™ 3" high flow system, Conventional Oxygen Therapy
NCT06674629 completednot on this mapstarted 2024, after this paper: background citation

Effects of an Asymmetrical High Flow Nasal Cannula Interface on End-Expiratory Lung Impedance

TypeobservationalSponsorArgentinian Intensive Care SocietyRan2024 to 2025Enrolled17ConditionsEnd-Expiratory Lung Impedance, Respiratory Rate, Diaphragm Thickness Fraction, Diaphragm ExcursionArmsHigh flow oxygen therapy
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 9 syntheses or guidelines pooled it, 207 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Guideline
  6. Pooled it
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  9. Pooled it
  10. Trial
  11. Nasal High-flow Oxygen Versus Conventional Oxygen Therapy for Acute Severe Asthma Patients: A Pilot Randomized Controlled Trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021
    Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. High-flow nasal oxygen in anesthesiology practice.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026
    Review
  17. Article
  18. Article
  19. Observational
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Oriol RocaCritical Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute, Barcelona, Spain. oroca@vhebron.net.
Gonzalo HernándezCritical Care Department, Virgen de la Salud Hospital, Toledo, Spain.
Salvador Díaz-LobatoRespiratory Medicine Department, Ramón y Cajal University Hospital, Madrid, Spain.
José M CarrataláEmergency Medicine Department, Alicante General Hospital, Alicante, Spain.
Rosa M GutiérrezAnesthesiology Department, De Cruces General Hospital, Bilbao, Spain.
Joan R MasclansCiber Enfermedades Respiratorias (Ciberes), Instituto de Salud Carlos III, Madrid, Spain.
Spanish Multidisciplinary Group of High Flow Supportive Therapy in Adults (HiSpaFlow)
Instituto de Salud Carlos III · ESInstituto Cajal · ESHebron University · PSHospital de Cruces · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High flow nasal cannula (HFNC) supportive therapy has emerged as a safe, useful therapy in patients with respiratory failure, improving oxygenation and comfort. Recently several clinical trials have analyzed the effectiveness of HFNC therapy in different clinical situations and have reported promising results. Here we review the current knowledge about HFNC therapy, from its mechanisms of action to its effects on outcomes in different clinical situations.

Indexed as

CannulaHumidifiersAdultHumansOxygen Inhalation TherapyRespiratory InsufficiencyHigh flow nasal cannulaHigh flow oxygen therapyRespiratory failure

Identifiers

PMID27121707
PMCPMC4848798
OpenAlexW2341347386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.