ArticleBiomedical materials (Bristol, England)2016
Rapid fabrication of poly(DL-lactide) nanofiber scaffolds with tunable degradation for tissue engineering applications by air-brushing.
Article in Biomedical materials (Bristol, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Injectable Short Nanofiber Fragments Enable Conformal Fibrous Scaffolds for Tissue Engineering on Complex Surfaces.Macromolecular rapid communications · 2026Article
- Pneumatospinning Biomimetic Scaffolds for Meniscus Tissue Engineering.Frontiers in bioengineering and biotechnology · 2022Article
- Pressure-Sensitive Tissue Adhesion and Biodegradation of Viscoelastic Polymer Blends.ACS applied materials & interfaces · 2020Article
- A step toward engineering thick tissues: Distributing microfibers within 3D printed frames.Journal of biomedical materials research. Part A · 2020Article
- Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective.Nanomaterials (Basel, Switzerland) · 2019Review
- A Non-woven Path: Electrospun Poly(lactic acid) Scaffolds for Kidney Tissue Engineering.Tissue engineering and regenerative medicine · 2018Article
- A Review of the Fundamental Principles and Applications of Solution Blow Spinning.ACS applied materials & interfaces · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Polymer nanofiber based materials have been widely investigated for use as tissue engineering scaffolds. While promising, these materials are typically fabricated through techniques that require significant time or cost. Here we report a rapid and cost effective air-brushing method for fabricating nanofiber scaffolds using a simple handheld apparatus, compressed air, and a polymer solution. Air-brushing also facilities control over the scaffold degradation rate without adversely impacting architecture. This was accomplished through a one step blending process of high (M w ≈ 100 000 g mol(-1)) and low (M w ≈ 25 000 g mol(-1)) molecular weight poly(DL-lactide) (PDLLA) polymers at various ratios (100:0, 70:30 and 50:50). Through this approach, we were able to control fiber scaffold degradation rate while maintaining similar fiber morphology, scaffold porosity, and bulk mechanical properties across all of the tested compositions. The impact of altered degradation rates was biologically evaluated in human bone marrow stromal cell (hBMSC) cultures for up to 16 days and demonstrated degradation rate dependence of both total DNA concentration and gene regulation.
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Registered trials
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