Evidence map›Paper›PMID 27121651›Full record

ReviewNature reviews. Immunology2016

MicroRNAs as regulatory elements in immune system logic.

Arnav Mehta, David Baltimore

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 401 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
401citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

401 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Exploring dysregulated miRNAs in ALS: implications for disease pathogenesis and early diagnosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  11. Are RNA Therapies a Solid Foundation or a Frontier Yet to Be Conquered?International journal of molecular sciences · 2026
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341 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Arnav MehtaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 90025, USA.
David BaltimoreDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 90025, USA.

Funding

MicroRNA Function in the Immune SystemR01AI079243 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BALTIMORE, DAVID · 2008 to 2018
$4.1M
MicroRNA-125b physiologically and pathologically regulates myelopoiesis through IF30CA183220 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MEHTA, ARNAV · 2014 to 2015
$82k
NCI NIH HHS F30 CA183220NIAID NIH HHS R01 AI079243
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate decisions. They act by negatively regulating the expression of key immune development genes, thus contributing important logic elements to the regulatory circuitry. Deletion studies have made it increasingly apparent that they confer robustness to immune cell development, especially under conditions of environmental stress such as infectious challenge and ageing. Aberrant expression of certain miRNAs can lead to pathological consequences, such as autoimmunity and haematological cancers. In this Review, we discuss the mechanisms by which several miRNAs influence immune development and buffer normal haematopoietic output, first at the level of haematopoietic stem cells, then in innate and adaptive immune cells. We then discuss the pathological consequences of dysregulation of these miRNAs.

Indexed as

Gene Expression RegulationAdaptive ImmunityAnimalsAutoimmunityCell DifferentiationDisease SusceptibilityHematopoietic Stem CellsHomeostasisHumansImmune SystemImmunity, InnateImmunomodulationMicroRNAsMicroRNAs

Identifiers

PMID27121651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.