ArticleScientific reports2016
Two types of interneurons in the mouse lateral geniculate nucleus are characterized by different h-current density.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- KArchiv der Pharmazie · 2026Review
- A High-Resolution Transcriptomic Atlas of Cell Types in the Ventral Visual Thalamus.Journal of neurochemistry · 2026Article
- Local thalamic interneurons drive spindle termination and enable sleep-dependent learning.bioRxiv : the preprint server for biology · 2025Article
- Enhanced Synaptic Inhibition in the Dorsolateral Geniculate Nucleus in a Mouse Model of Glaucoma.eNeuro · 2024Article
- The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Deprivation-Induced Plasticity in the Early Central Circuits of the Rodent Visual, Auditory, and Olfactory Systems.eNeuro · 2024Review
- 3D electron microscopy and volume-based bouton sorting reveal the selectivity of inputs onto geniculate relay cell and interneuron dendrite segments.Frontiers in neuroanatomy · 2023Article
- Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus.eLife · 2022Article
- Daily changes in light influence mood via inhibitory networks within the thalamic perihabenular nucleus.Science advances · 2022Article
- The organization of cholinergic projections in the visual thalamus of the mouse.The Journal of comparative neurology · 2022Article
- Thalamic subnetworks as units of function.Nature neuroscience · 2022Review
- Morphology, physiology and synaptic connectivity of local interneurons in the mouse somatosensory thalamus.The Journal of physiology · 2021Article
- Diverse GABAergic neurons organize into subtype-specific sublaminae in the ventral lateral geniculate nucleus.Journal of neurochemistry · 2021Article
- Article
- Synaptic properties of the feedback connections from the thalamic reticular nucleus to the dorsal lateral geniculate nucleus.Journal of neurophysiology · 2020Article
- Retinal inputs signal astrocytes to recruit interneurons into visual thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- PatcherBot: a single-cell electrophysiology robot for adherent cells and brain slices.Journal of neural engineering · 2019Article
- Properties of neurons in the superficial laminae of trigeminal nucleus caudalis.Physiological reports · 2019Article
- Developmental Remodeling of Thalamic Interneurons Requires Retinal Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels and the corresponding h-current (Ih) have been shown to fundamentally shape the activity pattern in the thalamocortical network, little is known about their function in local circuit GABAergic interneurons (IN) of the dorsal part of the lateral geniculate nucleus (dLGN). By combining electrophysiological, molecular biological, immunohistochemical and cluster analysis, we characterized the properties of Ih and the expression profile of HCN channels in IN. Passive and active electrophysiological properties of IN differed. Two subclasses of IN were resolved by unsupervised cluster analysis. Small cells were characterized by depolarized resting membrane potentials (RMP), stronger anomalous rectification, higher firing frequency of faster action potentials (APs), appearance of rebound bursting, and higher Ih current density compared to the large IN. The depolarization exerted by sustained HCN channel activity facilitated neuronal firing. In addition to cyclic nucleotides, Ih in IN was modulated by PIP2 probably based on the abundant expression of the HCN3 isoform. Furthermore, only IN with larger cell diameters expressed neuronal nitric oxide synthase (nNOS). It is discussed that Ih in IN is modulated by neurotransmitters present in the thalamus and that the specific properties of Ih in these cells closely reflect their modulatory options.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.