ReviewNature reviews. Cardiology2016
Pathophysiology and management of multivalvular disease.
Review in Nature reviews. Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Multivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis.Future cardiology · 2025Pooled it
- Design Variation, Implantation, and Outcome of Transcatheter Mitral Valve Prosthesis: A Comprehensive Review.Frontiers in cardiovascular medicine · 2021Pooled it
- The Brazilian Society of Cardiology and Brazilian Society of Exercise and Sports Medicine Updated Guidelines for Sports and Exercise Cardiology - 2019.Arquivos brasileiros de cardiologia · 2019Guideline
- Multivalvular Involvement in Acute Heart Failure: Associations with One-Year Outcomes and the Right-Heart Phenotype.Medical sciences (Basel, Switzerland) · 2026Article
- Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications.Heart failure reviews · 2026Review
- Current and Emerging Treatments for Isolated Aortic Stenosis and Concomitant Mitral Stenosis: A Comprehensive Narrative Review.Journal of clinical medicine · 2026Review
- Rational and design of EACVI-MMVD study: an international registry on multimodality imaging for mixed and multiple valvular heart disease.European heart journal. Imaging methods and practice · 2026Article
- The Prognosis of Males and Females With Moderate or Severe Secondary Mitral Valve Regurgitation and Avenues for Improvement.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Characteristics and Problems of Rheumatic Heart Disease in Indonesia: The Ina-RHD Multicenter Study.JACC. Asia · 2025Article
- Epidemiology of Valvular Heart Disease in Asia Pacific Region.JACC. Asia · 2025Review
- Severe mitral stenosis as a cause of paradoxical low-flow, low-gradient severe aortic stenosis: an explorative study on hemodynamics and outcomes.Frontiers in cardiovascular medicine · 2025Article
- Recovery of left ventricular function after surgery for aortic and mitral regurgitation with heart failure.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- The Molecular Mechanisms Underlying the Systemic Effects Mediated by Parathormone in the Context of Chronic Kidney Disease.Current issues in molecular biology · 2024Review
- Expert proposal to analyze the combination of aortic and mitral regurgitation in multiple valvular heart disease by comprehensive echocardiography.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- Clinical Outcomes after Multivalve Surgery in Octogenarians: Evaluating the Need for a Paradigm Shift.Journal of clinical medicine · 2024Article
- Prognostic Impact of Residual Moderate Mitral Regurgitation Following Valve-in-Valve Transcatheter Aortic Valve Implantation.Brazilian journal of cardiovascular surgery · 2023Article
- Beyond Aortic Stenosis: Addressing the Challenges of Multivalvular Disease Assessment.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- Simultaneous Hybrid Transcatheter Aortic Valve Implantation and Endoscopic Mitral Valve Repair.CJC open · 2023Article
- Treatment of Moderate Functional Mitral Regurgitation during Aortic Valve Replacement: A Cohort Study.Reviews in cardiovascular medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Multivalvular disease (MVD) is common among patients with valvular disease, and has a complex pathophysiology dependent on the specific combination of valve lesions. Diagnosis is challenging because several echocardiographic methods commonly used for the assessment of stenosis or regurgitation have been validated only in patients with single-valve disease. Decisions about the timing and type of treatment should be made by a multidisciplinary heart valve team, on a case-by-case basis. Several factors should be considered, including the severity and consequences of the MVD, the patient's life expectancy and comorbidities, the surgical risk associated with combined valve procedures, the long-term risk of morbidity and mortality associated with multiple valve prostheses, and the likelihood and risk of reoperation. The introduction of transcatheter valve therapies into clinical practice has provided new treatment options for patients with MVD, and decision-making algorithms on how to combine surgical and percutaneous treatment options are evolving rapidly. In this Review, we discuss the pathophysiology, diagnosis, and treatment of MVD, focusing on the combinations of valve pathologies that are most often encountered in clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.