ArticleAngewandte Chemie (International ed. in English)2016
Measuring the Elasticity of Poly-l-Proline Helices with Terahertz Spectroscopy.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Young's modulus from terahertz spectroscopy and first-principles calculations as an effective indicator of impact sensitivity for molecular perovskite energetic materials.Journal of molecular modeling · 2026Article
- Structure-Dynamics-Property Relationship Reveals the Origin of Porous Integrity in Imine-Linked Covalent Organic Frameworks.Journal of the American Chemical Society · 2026Article
- Interrogation of the Intermolecular Forces That Drive Bulk Properties of Molecular Crystals with Terahertz Spectroscopy and Density Functional Theory.Crystal growth & design · 2025Article
- Electrostatic enhanced terahertz metamaterial biosensing via gold nanoparticles integrated with biomolecules.Scientific reports · 2025Article
- Is Ortho-Terphenyl a Rigid Glass Former?The journal of physical chemistry letters · 2024Article
- Water-assisted and protein-initiated fast and controlled ring-opening polymerization of prolineNational science review · 2022Article
- Understanding the Targeting Mechanisms of Multi-Specific Biologics in Immunotherapy with Multiscale Modeling.iScience · 2020Article
- Investigation of theRSC advances · 2020Article
- Intrinsically disordered proteins access a range of hysteretic phase separation behaviors.Science advances · 2019Article
- Terahertz Spectroscopy of Tetrameric Peptides.The journal of physical chemistry letters · 2019Article
- Solvent Mediation of Peptide Conformations: Polyproline Structures in Water, Methanol, Ethanol, and 1-Propanol as Determined by Ion Mobility Spectrometry-Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2019Article
- Measuring the Elasticity of Poly-l-Proline Helices with Terahertz Spectroscopy.Angewandte Chemie (International ed. in English) · 2016Article
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5 authors.
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Abstract
The rigidity of poly-l-proline is an important contributor to the stability of many protein secondary structures, where it has been shown to strongly influence bulk flexibility. The experimental Young's moduli of two known poly-l-proline helical forms, right-handed all-cis (Form I) and left-handed all-trans (Form II), were determined in the crystalline state by using an approach that combines terahertz time-domain spectroscopy, X-ray diffraction, and solid-state density functional theory. Contrary to expectations, the helices were found to be considerably less rigid than many other natural and synthetic polymers, as well as differing greatly from each other, with Young's moduli of 4.9 and 9.6 GPa for Forms I and II, respectively.
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