Evidence map›Paper›PMID 27121294›Full record

ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2016

Metabolomic patterns associated to QTc interval in shiftworkers: an explorative analysis.

Marcello Campagna, Emanuela Locci, Roberto Piras, Antonio Noto, Luigi Isaia Lecca, Ilaria Pilia, Pierluigi Cocco, Ernesto d'Aloja, Paola Scano

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Association between Work-Related Stress and QT Prolongation in Male Workers.International journal of environmental research and public health · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marcello Campagnaa Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Emanuela Loccia Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Roberto Pirasa Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Antonio Notoa Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Luigi Isaia Leccaa Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Ilaria Piliaa Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Pierluigi Coccoa Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Ernesto d'Alojaa Department of Public Health, Clinical and Molecular Medicine , University of Cagliari , Cagliari , Italy ;
Paola Scanob Department of Chemical and Geological Sciences , University of Cagliari , Cagliari , Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectives(1)H NMR-metabolomic approach was used to investigate QTc interval correlation with plasma metabolic profiles in shiftworkers.

methodsSocio-demographic data, electrocardiographic QTc interval and plasma metabolic profiles from 32 male shiftworkers, were correlated by multivariate regression analysis.

resultsWe found a positive correlation between QTc interval values, body mass index, glycemia and lactate level and a negative correlation between QTc interval and both pyroglutamate and 3-hydroxybutyrate plasma level.

conclusionsOur analysis provides evidence of the association between clinical, metabolic profiles and QTc interval values. This could be used to identify markers of early effects and/or susceptibility in shiftworkers.

Indexed as

ElectrocardiographyMetabolomicsHumansLong QT SyndromeMaleOccupational HealthRegression AnalysisWork Schedule ToleranceMetabolomicsQT prolongationshiftwork

Identifiers

PMID27121294
PMCPMC5359777

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.