Evidence map›Paper›PMID 27121234›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Impact of Perioperative Phosphorus and Glucose Levels on Liver Regeneration and Long-term Outcomes after Major Liver Resection.

Georgios Antonios Margonis, Neda Amini, Stefan Buettner, Mounes Aliyari Ghasebeh, Sepideh Besharati, Yuhree Kim, Faiz Gani, Fatemeh Sobhani, Mario Samaha, Ihab R Kamel and 1 more

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Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Georgios Antonios MargonisDivision of Surgical Oncology John L. Cameron Professor of Alimentary Surgery Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Neda AminiDivision of Surgical Oncology John L. Cameron Professor of Alimentary Surgery Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Stefan BuettnerDivision of Surgical Oncology John L. Cameron Professor of Alimentary Surgery Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Mounes Aliyari GhasebehDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sepideh BesharatiDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuhree KimDivision of Surgical Oncology John L. Cameron Professor of Alimentary Surgery Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Faiz GaniDivision of Surgical Oncology John L. Cameron Professor of Alimentary Surgery Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Fatemeh SobhaniDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mario SamahaDivision of Surgical Oncology John L. Cameron Professor of Alimentary Surgery Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Ihab R KamelDepartment of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Timothy M PawlikDivision of Surgical Oncology John L. Cameron Professor of Alimentary Surgery Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA. tpawlik1@jhmi.edu.
Johns Hopkins Hospital · USJohns Hopkins University · USJohns Hopkins Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe impact of phosphorus as well as glycemic alterations on liver regeneration has not been directly examined. We sought to determine the impact of phosphorus and glucose on liver regeneration after major hepatectomy.

methodsEarly and late liver regeneration index was defined as the relative increase of liver volume (RLV) within 2[(RLV2m-RLVp)/RLVp] and 7 months[(RLV7m-RLVp)/RLVp] following surgery. The association of perioperative metabolic factors, liver regeneration, and outcomes was assessed.

resultsOn postoperative day 2, 50 (52.6 %) patients had a low phosphorus level (≤2.4 mg/dl), while 45 (47.4 %) had a normal/high phosphorus level (>2.4 mg/dl). Despite comparable clinicopathologic characteristics (all P > 0.05) and RLV/TLV at surgery (P = 0.84), regeneration index within 2 months was lower in the normal/high phosphorus group (P = 0.01) with these patients having increased risk for postoperative liver failure (P = 0.01). The inhibition of liver regeneration persisted at 7 months (P = 0.007) and was associated with a worse survival (P = 0.02). Preoperative hypoglycemia was associated only with a lower early regeneration index (P = 0.02).

conclusionsNormal/high phosphorus was associated with inhibition of early and late liver regeneration, as well as with an increased risk of liver failure and worse long-term outcomes. Immediate preoperative hypoglycemia was associated with a lower early volumetric gain. Metabolic factors may represent early indicators of liver failure that could identify patients at increased risk for worse outcomes.

Indexed as

AgedBlood GlucoseFemaleHepatectomyHumansLiver DiseasesLiver FailureLiver NeoplasmsLiver RegenerationMaleMiddle AgedOrgan SizePhosphorusPostoperative PeriodBlood GlucosePhosphorusGlucoseHepatectomyLiver regenerationPhosphorus

Identifiers

PMID27121234
OpenAlexW2345003502

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.