Evidence map›Paper›PMID 27121233›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Assessing Trends in Palliative Surgery for Extrahepatic Biliary Malignancies: A 15-Year Multicenter Study.

Stefan Buettner, Ana Wilson, Georgios Antonis Margonis, Faiz Gani, Cecilia G Ethun, George A Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields and 13 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Early Palliative Care Following Aborted Cancer Surgery: Results of a Prospective Feasibility Trial.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. [Intrahepatic cholangiocarcinoma : Results after 84 resections].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 11 institutions in 1 country.

Stefan BuettnerDepartment of Surgery, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Ana WilsonDepartment of Surgery, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Georgios Antonis MargonisDepartment of Surgery, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Faiz GaniDepartment of Surgery, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA.
Cecilia G EthunDepartment of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
George A PoultsidesDepartment of Surgery, Stanford University Medical Center, Stanford, CA, USA.
Thuy TranDepartment of Surgery, Stanford University Medical Center, Stanford, CA, USA.
Kamran IdreesDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Chelsea A IsomDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Ryan C FieldsDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Bradley KrasnickDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Sharon M WeberDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Ahmed SalemDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Robert C G MartinDepartment of Surgery, University of Louisville, Louisville, KY, USA.
Charles R ScogginsDepartment of Surgery, University of Louisville, Louisville, KY, USA.
Perry ShenDepartment of Surgery, Wake Forest University, Winston-Salem, NC, USA.
Harveshp D MogalDepartment of Surgery, Wake Forest University, Winston-Salem, NC, USA.
Carl SchmidtDepartment of Surgery, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Eliza BealDepartment of Surgery, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Ioannis HatzarasDepartment of Surgery, New York University, New York, NY, USA.
Rivfka ShenoyDepartment of Surgery, New York University, New York, NY, USA.
Shishir K MaithelDepartment of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Timothy M PawlikDepartment of Surgery, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Blalock 688, Baltimore, MD, 21287, USA. tpawlik1@jhmi.edu.
Johns Hopkins University · USEmory University · USNew York University · USStanford Medicine · USThe Ohio State University · USUniversity of Louisville · USUniversity of Wisconsin–Madison · USVanderbilt University Medical Center · USWake Forest University · USWashington University in St. Louis · USJohns Hopkins Medicine · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Advanced Research Training in Immunology for Surgery Trainees (ARTIST)T32AI106704 · NIAID · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER, Jon R Wisler · 2014 to 2026
$3.5M
NCI NIH HHS K12 CA090625NCI NIH HHS P30 CA016058NIAID NIH HHS T32 AI106704
6 · The paper itself

Abstract

introductionExtrahepatic biliary malignancies are often diagnosed at an advanced stage. We compared patients with unresectable perihilar cholangiocarcinoma (PHCC) and gallbladder cancer (GBC) who underwent a palliative procedure versus an aborted laparotomy.

methodsSeven hundred seventy-seven patients who underwent surgery for PHCC or GBC between 2000 and 2014 were identified. Uni- and multivariable analyses were performed to identify factors associated with outcome.

resultsUtilization of preoperative imaging increased over time (CT use, 80.1 % pre-2009 vs. 90 % post-2009) (p < 0.001). The proportion of the patients undergoing curative-intent resection also increased (2000-2004, 67.0 % vs. 2005-2009, 74.5 % vs. 2010-2014, 78.8 %; p = 0.001). The planned surgery was aborted in 106 (13.7 %) patients and 94 (12.1 %) had a palliative procedure. A higher incidence of postoperative complications (19.2 vs. 3.8 %, p = 0.001) including deep surgical site infections (8.3 vs. 1.1 %), bleeding (4.8 vs. 0 %), bile leak (6.0 vs. 0 %) and longer length of stay (7 vs. 4.5 days) were observed among the patients who underwent a palliative surgical procedure versus an aborted non-therapeutic, non-palliative laparotomy (all p < 0.05). OS was comparable among the patients who underwent a palliative procedure (8.7 months) versus an aborted laparotomy (7.8 months) (p = 0.23).

conclusionIncreased use of advanced imaging modalities was accompanied by increased curative-intent surgery. Compared with patients in whom surgery was aborted, patients who underwent surgical palliation demonstrated an increased incidence of postoperative morbidity with comparable survival.

Indexed as

AgedBile Duct NeoplasmsFemaleGallbladder NeoplasmsHumansKlatskin TumorLaparotomyLength of StayMaleMiddle AgedPalliative CarePostoperative ComplicationsPostoperative HemorrhageSurgical Wound InfectionTomography, X-Ray ComputedBiliaryExtrahepaticMalignancyPalliationSurgical

Identifiers

PMID27121233
PMCPMC5450034
OpenAlexW2342419613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.