ArticleBone & joint research2016
Effectiveness and safety of recombinant human bone morphogenetic protein-2 for adults with lumbar spine pseudarthrosis following spinal fusion surgery: A systematic review.
Article in Bone & joint research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Allograft-Reconstructed Iliac Bone Graft Donor Site Remodels to Viable Bone and Its Feasibility for Revision Fusion.International journal of spine surgery · 2023Article
- The Role of BMP Signaling in Osteoclast Regulation.Journal of developmental biology · 2021Review
- A replicating stem-like cell that contributes to bone morphogenetic protein 2-induced heterotopic bone formation.Stem cells translational medicine · 2021Article
- The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc.International journal of molecular sciences · 2021Review
- Failure in Lumbar Spinal Fusion and Current Management Modalities.Seminars in plastic surgery · 2021Review
- TGF-β Activity of a Demineralized Bone Matrix.International journal of molecular sciences · 2021Article
- Article
- Osterix-mCherry Expression Allows for Early Bone Detection in a Calvarial Defect Model.Advanced biosystems · 2019Article
- Application of Cytokines of the Bone Morphogenetic Protein (BMP) Family in Spinal Fusion - Effects on the Bone, Intervertebral Disc and Mesenchymal Stromal Cells.Current stem cell research & therapy · 2019Review
- Minor Review: An Overview of a Synthetic Nanophase Bone Substitute.Materials (Basel, Switzerland) · 2018Review
- Inhibitory Effects of Human Primary Intervertebral Disc Cells on Human Primary Osteoblasts in a Co-Culture System.International journal of molecular sciences · 2018Article
- Local delivery of a novel PTHrPRSC advances · 2018Article
- Controlled JAGGED1 delivery induces human embryonic palate mesenchymal cells to form osteoblasts.Journal of biomedical materials research. Part A · 2018Article
- Site-specific chromosomal gene insertion: Flp recombinase versus Cas9 nuclease.Scientific reports · 2017Article
- Equipoise and the technology curve: Relevance in the design of Surgical trials.Bone & joint research · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe performed a systematic review of the literature to determine the safety and efficacy of bone morphogenetic protein (BMP) compared with bone graft when used specifically for revision spinal fusion surgery secondary to pseudarthrosis.
methodsThe MEDLINE, EMBASE and Cochrane Library databases were searched using defined search terms. The primary outcome measure was spinal fusion, assessed as success or failure in accordance with radiograph, MRI or CT scan review at 24-month follow-up. The secondary outcome measure was time to fusion.
resultsA total of six studies (three prospective and three retrospective) reporting on the use of BMP2 met the inclusion criteria (203 patients). Of these, four provided a comparison of BMP2 and bone graft whereas the other two solely investigated the use of BMP2. The primary outcome was seen in 92.3% (108/117) of patients following surgery with BMP2. Although none of the studies showed superiority of BMP2 to bone graft for fusion, its use was associated with a statistically quicker time to achieving fusion. BMP2 did not appear to increase the risk of complication.
conclusionThe use of BMP2 is both safe and effective within the revision setting, ideally in cases where bone graft is unavailable or undesirable. Further research is required to define its optimum role.Cite this article: Mr P. Bodalia. Effectiveness and safety of recombinant human bone morphogenetic protein-2 for adults with lumbar spine pseudarthrosis following spinal fusion surgery: A systematic review. Bone Joint Res 2016;5:145-152. DOI: 10.1302/2046-3758.54.2000418.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.