ArticleOncotarget2016
Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Pooled it
- Pooled it
- Apoptotic Factors Are Evolutionarily Conserved Since Mitochondrial Domestication.Genome biology and evolution · 2023Article
- The anticancer effect of recombinant LukS-PV protein and silver nanoparticles loaded with this protein.AMB Express · 2023Article
- Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?Microorganisms · 2022Review
- Role of TRPM2 in brain tumours and potential as a drug target.Acta pharmacologica Sinica · 2022Review
- Botulinum toxin in cancer therapy-current perspectives and limitations.Applied microbiology and biotechnology · 2022Review
- Model-Based Anticancer Effect of Botulinum Neurotoxin Type A1 on Syngeneic Melanoma Mice.Frontiers in pharmacology · 2021Article
- Mobilizing Toxins for Cancer Treatment: Historical Perspectives and Current Strategies.Toxins · 2020Article
- Duplication of clostridial binding domains for enhanced macromolecular delivery into neurons.Toxicon: X · 2020Article
- Review
- Symbiotic Origin of Apoptosis.Results and problems in cell differentiation · 2020Article
- Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity.Toxins · 2018Review
- Ancestral State Reconstruction of the Apoptosis Machinery in the Common Ancestor of Eukaryotes.G3 (Bethesda, Md.) · 2018Article
- Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.PLoS pathogens · 2017Article
- Low Dose of Bisphenol A Activates NF-κB/IL-6 Signals to Increase Malignancy of Neuroblastoma Cells.Cellular and molecular neurobiology · 2017Article
- A Cell Line for Detection of Botulinum Neurotoxin Type B.Frontiers in pharmacology · 2017Article
- SNAP23 promotes the malignant process of ovarian cancer.Journal of ovarian research · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human neuroblastoma cells to protease activity derived from botulinum neurotoxin type C. We show that following retinoic acid treatment, human neuroblastoma cells, SiMa and SH-SY5Y, acquire a neuronal phenotype evidenced by axonal growth and expression of neuronal markers. Botulinum neurotoxin type C which cleaves neuron-specific SNAP25 and syntaxin1 caused apoptotic death only in differentiated neuroblastoma cells. Direct comparison of translation-inhibiting enzymes and the type C botulinum protease revealed one order higher cytotoxic potency of the latter suggesting a novel neuroblastoma-targeting pathway. Our mechanistic insights revealed that loss of ubiquitous SNAP23 due to differentiation coupled to SNAP25 cleavage due to botulinum activity may underlie the apoptotic death of human neuroblastoma cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.