ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2016
Genome-wide association studies of drought-related metabolic changes in maize using an enlarged SNP panel.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 66 citations in OpenAlex.
- Multienvironment multilocus association mapping reveals genomic regions for drought-related traits in tropical maize.G3 (Bethesda, Md.) · 2026Article
- Comprehensive evaluation of compound saline-alkali tolerance and gene mining by GWAS in Vicia faba L.BMC plant biology · 2025Article
- Genetic dissection of plant height-related traits by combined methods in wheat (Triticum aestivum L.).BMC plant biology · 2025Article
- Review
- Phenotypic Investigation and RNA-seq ofInternational journal of molecular sciences · 2024Article
- Maize green leaf area index dynamics: genetic basis of a new secondary trait for grain yield in optimal and drought conditions.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Identification of Novel QTL for Mercury Accumulation in Maize Using an Enlarged SNP Panel.Genes · 2024Article
- Advancements and Prospects of Genome-Wide Association Studies (GWAS) in Maize.International journal of molecular sciences · 2024Review
- Identification of novel loci associated with starch content in maize kernels by a genome-wide association study using an enlarged SNP panel.Molecular breeding : new strategies in plant improvement · 2023Article
- Molecular mechanisms of drought resistance using genome-wide association mapping in maize (Zea mays L.).BMC plant biology · 2023Article
- Hybrid performance evaluation and genome-wide association analysis of root system architecture in a maize association population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Dissecting the Genetic Structure of Maize Leaf Sheaths at Seedling Stage by Image-Based High-Throughput Phenotypic Acquisition and Characterization.Frontiers in plant science · 2022Article
- Genome-Wide Association Analysis for Candidate Genes Contributing to Kernel-Related Traits in Maize.Frontiers in plant science · 2022Article
- Recent Advances for Drought Stress Tolerance in Maize (Frontiers in plant science · 2022Review
- Genome-wide association study of coleoptile length with Shanxi wheat.Frontiers in plant science · 2022Article
- Recent developments in multi-omics and breeding strategies for abiotic stress tolerance in maize (Frontiers in plant science · 2022Review
- Improving drought tolerance in maize: Tools and techniques.Frontiers in genetics · 2022Review
- Characterization and genetic dissection of maize ear leaf midrib acquired by 3D digital technology.Frontiers in plant science · 2022Article
- Genomic basis underlying the metabolome-mediated drought adaptation of maize.Genome biology · 2021Article
- The utility of metabolomics as a tool to inform maize biology.Plant communications · 2021Review
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageGenetic determinants of metabolites related to drought tolerance in maize. Water deficit or drought is one of the most serious abiotic stresses of plant development and greatly reduces crop production, and the plant's response to this deficit leads to many metabolic changes. To dissect the genetic basis of these metabolic traits in maize, we performed a genome-wide association analysis of drought-related traits using 156,599 SNPs in 318 maize inbred lines. In total, 123 significant SNP/trait associations (P ≤ 6.39E-6) involving 63 loci were identified for related metabolic and physiological traits in multiple tissues and different environments under two irrigation conditions. Of the 63, 23 loci demonstrated a significant interaction effect between QTL and water status, indicating that these metabolite-associated loci were probably related to drought stress tolerance. To evaluate the potential utility of metabolite-associated loci applied in hybrid maize breeding, we assembled two groups of hybrid entries with high or low drought tolerance and measured the metabolic and physiological traits. In the hybrid pools, a set of 10 metabolite-associated loci identified in leaf and ear were validated as responsive to drought stress. The favorable alleles of these ten loci were significantly enriched in hybrids with high drought tolerance, which jointly explained almost 18.4 % of the variation in drought tolerance using a multivariate logistic regression model. These results provide clues to understanding the genetic basis of metabolic and physiological changes related to drought tolerance, potentially facilitating the genetic improvement of varieties with high drought tolerance in maize breeding programs.
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