SynthesisInternational braz j urol : official journal of the Brazilian Society of Urology
Male fertility potential alteration in rheumatic diseases: a systematic review.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Potential causes and associated conditions with anti-sperm antibody production among infertile males: a systematic literature review.BMC immunology · 2025Pooled it
- Adjuvant-induced arthritis induces epithelial proliferation and differential expression of SVS2 and SVS3 in the seminal vesicles.Andrology · 2026Article
- Article
- Testicular immunity.Molecular aspects of medicine · 2024Review
- Risk Assessment and Optimization for Pregnancy in Patients with Rheumatic Diseases.Diagnostics (Basel, Switzerland) · 2024Review
- Male patients with inflammatory joint diseases are less likely than controls to be childless: results from a Norwegian population-based cohort study of 10 865 patients.Annals of the rheumatic diseases · 2024Article
- Rituximab alleviates increased disomic sperm in DBA/1J mouse models of rheumatoid arthritis via restoration of redox imbalance.Journal of biochemical and molecular toxicology · 2023Article
- The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives.Journal of endocrinological investigation · 2022Review
- MANTA and MANTA-RAy: Rationale and Design of Trials Evaluating Effects of Filgotinib on Semen Parameters in Patients with Inflammatory Diseases.Advances in therapy · 2022Article
- Evolution of the World Health Organization semen analysis manual: where are we?Nature reviews. Urology · 2022Review
- Management of male factor infertility: position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS) : Endorsing Organization: Italian Society of Embryology, Reproduction, and Research (SIERR).Journal of endocrinological investigation · 2022Article
- Effects of Different Drug Therapies and COVID-19 mRNA Vaccination on Semen Quality in a Man with Ankylosing Spondylitis: A Case Report.Medicina (Kaunas, Lithuania) · 2022Article
- Adverse effect of rheumatoid arthritis on male Wistar rat's fertility: protective role of Costus extract.Environmental science and pollution research international · 2022Article
- Diverse selection pressures shaping the genetic architecture of behçet disease susceptibility.Frontiers in genetics · 2022Article
- Testicular thrombotic microangiopathy: An unrecognized complication.Pediatric blood & cancer · 2021Article
- Rheumatology-led pregnancy clinic: men perspective.Clinical rheumatology · 2021Review
- An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus.Paediatric drugs · 2021Review
- And When I Die: Theory of Planned Behavior as Applied to Sperm Cryopreservation.Healthcare (Basel, Switzerland) · 2021Article
- Telomere Length and Male Fertility.International journal of molecular sciences · 2021Article
- SARS-CoV-2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services.Andrology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImproved targeted therapies for rheumatic diseases were developed recently resulting in a better prognosis for affected patients. Nowadays, patients are living longer and with improved quality of life, including fertility potential. These patients are affected by impaired reproductive function and the causes are often multifactorial related to particularities of each disease. This review highlights how rheumatic diseases and their management affect testicular function and male fertility. MATERIALS AND
methodsA systematic review of literature of all published data after 1970 was conducted. Data was collected about fertility abnormalities in male patients with systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis, ankylosing spondylitis, Behçet disease and gout. Two independent researchers carried out the search in online databases.
resultsA total of 19 articles were included addressing the following diseases: 7 systemic lupus erythematosus, 6 Behçet disease, 4 ankylosing spondylitis, 2 rheumatoid arthritis, 2 dermatomyositis and one gout. Systemic lupus erythematosus clearly affects gonadal function impairing spermatogenesis mainly due to antisperm antibodies and cyclophosphamide therapy. Behçet disease, gout and ankylosing spondylitis patients, including those under anti-TNF therapy in the latter disease, do not seem to have reduced fertility whereas in dermatomyositis, the fertility potential is hampered by disease activity and by alkylating agents. Data regarding rheumatoid arthritis is scarce, gonadal dysfunction observed as consequence of disease activity and antisperm antibodies.
conclusionsReduced fertility potential is not uncommon. Its frequency and severity vary among the different rheumatic diseases. Permanent infertility is rare and often associated with alkylating agent therapy.
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