ReviewEuropean journal of immunology2016
Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells.
Review in European journal of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Association of overweight/obesity and insulin resistance with activation of circulating innate lymphoid cells in women after gestational diabetes mellitus.Frontiers in immunology · 2025Observational
- Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation.GeroScience · 2022Article
- Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.Immunity · 2022Article
- Obesity-Mediated Immune Modulation: One Step Forward, (Th)2 Steps Back.Frontiers in immunology · 2022Review
- Adipose-derived cellular therapies prolong graft survival in an allogenic hind limb transplantation model.Stem cell research & therapy · 2021Article
- Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11.Mucosal immunology · 2021Article
- Immune outposts in the adventitia: One foot in sea and one on shore.Current opinion in immunology · 2020Review
- Is There an Association or Not?-Investigating the Association of Depressiveness, Physical Activity, Body Composition and Sleep With Mediators of Inflammation.Frontiers in psychiatry · 2020Article
- Article
- Contribution of adipogenesis to healthy adipose tissue expansion in obesity.The Journal of clinical investigation · 2019Review
- The role of innate lymphoid cells and T helper cell activation in type 2 diabetic patients: a protocol for a systematic review and meta-analysis.Systematic reviews · 2019Article
- Immune-Deficient Pfp/Rag2Cells · 2019Article
- Regulation of regulatory T cells in cancer.Immunology · 2019Review
- On the role of macrophages in the control of adipocyte energy metabolism.Endocrine connections · 2019Review
- Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33.Science immunology · 2019Article
- Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.Nature communications · 2019Article
- Group 2 Innate Lymphoid Cells in Respiratory Allergic Inflammation.Frontiers in immunology · 2019Review
- Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors.International journal of molecular sciences · 2018Review
- Negative Regulation of Type 2 Immunity.Trends in immunology · 2017Review
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Adipose tissue (AT) is home to an abundance of immune cells. With chronic obesity, inflammatory immune cells accumulate and promote insulin resistance and the progression to type 2 diabetes mellitus. In contrast, recent studies have highlighted the regulation and function of immune cells in lean, healthy AT, including those associated with type 2 or "allergic" immunity. Although traditionally activated by infection with multicellular helminthes, AT type 2 immunity is active independently of infection, and promotes tissue homeostasis, AT "browning," and systemic insulin sensitivity, protecting against obesity-induced metabolic dysfunction and type 2 diabetes mellitus. In particular, group 2 innate lymphoid cells (ILC2s) are integral regulators of AT type 2 immunity, producing the cytokines interleukin-5 and IL-13, promoting eosinophils and alternatively activated macrophages, and cooperating with and promoting AT regulatory T (Treg) cells. In this review, we focus on the recent developments in our understanding of group 2 innate lymphoid cell cells and type 2 immunity in AT metabolism and homeostasis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.