ArticlePLoS genetics2016
An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 45 citations in OpenAlex.
- Naturally Occurring Variability in the Regulatory Region of theInternational journal of molecular sciences · 2026Article
- Pervasive tissue-, genetic background-, and allele-specific gene expression effects in Drosophila melanogaster.PLoS genetics · 2024Article
- Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Gene expression variation underlying tissue-specific responses to copper stress inbioRxiv : the preprint server for biology · 2023Article
- The genetic basis of adaptation to copper pollution inFrontiers in genetics · 2023Article
- The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors.BMC biology · 2022Article
- Temperature-dependent Small RNA Expression Depends on Wild Genetic Backgrounds of Caenorhabditis briggsae.Molecular biology and evolution · 2022Article
- Tunicates Illuminate the Enigmatic Evolution of Chordate Metallothioneins by Gene Gains and Losses, Independent Modular Expansions, and Functional Convergences.Molecular biology and evolution · 2021Article
- Rapid Evolutionary Adaptation in Response to Selection on Quantitative Traits.Life (Basel, Switzerland) · 2021Review
- Modularity in Protein Evolution: Modular Organization and De Novo Domain Evolution in Mollusk Metallothioneins.Molecular biology and evolution · 2021Article
- Modular Evolution and Population Variability ofFrontiers in cell and developmental biology · 2021Article
- Characterization and differential expression of sucrose and starch metabolism genes in contrasting chickpea (Journal of genetics · 2021Article
- Understanding the Early Evolutionary Stages of a Tandem Drosophilamelanogaster-Specific Gene Family: A Structural and Functional Population Study.Molecular biology and evolution · 2020Article
- Polygenic Adaptation in a Population of Finite Size.Entropy (Basel, Switzerland) · 2020Review
- Detecting Positive Selection in Populations Using Genetic Data.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Three Quantitative Trait Loci Explain More than 60% of Variation for Chill Coma Recovery Time in a Natural Population ofG3 (Bethesda, Md.) · 2019Article
- Drift and Directional Selection Are the Evolutionary Forces Driving Gene Expression Divergence in Eye and Brain Tissue ofGenetics · 2019Article
- A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila.Evolution; international journal of organic evolution · 2019Article
- Many Options, Few Solutions: Over 60 My Snakes Converged on a Few Optimal Venom Formulations.Molecular biology and evolution · 2019Article
- Review
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insertions and deletions (indels) are a major source of genetic variation within species and may result in functional changes to coding or regulatory sequences. In this study we report that an indel polymorphism in the 3' untranslated region (UTR) of the metallothionein gene MtnA is associated with gene expression variation in natural populations of Drosophila melanogaster. A derived allele of MtnA with a 49-bp deletion in the 3' UTR segregates at high frequency in populations outside of sub-Saharan Africa. The frequency of the deletion increases with latitude across multiple continents and approaches 100% in northern Europe. Flies with the deletion have more than 4-fold higher MtnA expression than flies with the ancestral sequence. Using reporter gene constructs in transgenic flies, we show that the 3' UTR deletion significantly contributes to the observed expression difference. Population genetic analyses uncovered signatures of a selective sweep in the MtnA region within populations from northern Europe. We also find that the 3' UTR deletion is associated with increased oxidative stress tolerance. These results suggest that the 3' UTR deletion has been a target of selection for its ability to confer increased levels of MtnA expression in northern European populations, likely due to a local adaptive advantage of increased oxidative stress tolerance.
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