Evidence map›Paper›PMID 27120500›Full record

SynthesisTropical medicine & international health : TM & IH2016

HIV-free survival at 12-24 months in breastfed infants of HIV-infected women on antiretroviral treatment.

Lana Clara Chikhungu, Stephanie Bispo, Nigel Rollins, Nandi Siegfried, Marie-Louise Newell

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Tropical medicine & international health : TM & IH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Interventions to support breastfeeding among mothers living with HIV: A systematic review and meta-analysis of randomized controlled trials.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lana Clara ChikhunguSchool of Languages and Area Studies, University of Portsmouth, Portsmouth, UK.
Stephanie BispoDepartment of Social Statistics and Demography, University of Southampton, Southampton, UK.
Nigel RollinsDepartment of Maternal, New-born, Child and Adolescent Health, World Health Organization, Geneva, Switzerland.
Nandi SiegfriedIndependent Clinical Epidemiologist.
Marie-Louise NewellHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

Funding

World Health Organization 001
6 · The paper itself

Abstract

objectiveTo provide estimates of HIV-free survival at 12-24 months in breastfed children by maternal ART (6 months or lifelong) to inform WHO HIV and Infant Feeding guidelines.

methodsEighteen studies published 2005-2015 were included in a systematic literature review (1295 papers identified, 156 abstracts screened, 55 full texts); papers were analysed by narrative synthesis and meta-analysis of HIV-free survival by maternal ART regimen in a random effects model. We also grouped studies by feeding modality. Study quality was assessed using a modified Newcastle-Ottawa Scale (NOS) and GRADE.

resultsThe pooled estimates for 12-month HIV-free survival were 89.8% (95% confidence interval, CI: 86.5%, 93.2%) for infants of mothers on ART for 6 months post-natally (six studies) and 91.4% (95% CI 87.5%, 95.4%) for infants of mothers on lifelong ART (three studies). Eighteen-month HIV-free survival estimates were 89.0% (95% CI 83.9%, 94.2%) with 6 months ART (five studies) and 96.1% (95% CI 92.8%, 99.0%) with lifelong ART (three studies). Twenty-four-month HIV-free survival for infants whose mothers were on ART to 6 months post-natally (two studies) was 89.2% (95% CI 79.9%, 98.5%). Heterogeneity was considerable throughout. In four studies, HIV-free survival in breastfed infants ranged from 87% (95% CI 78%, 92%) to 96% (95% CI 91%, 98%) and in formula-fed infants from 67% (95% CI 35.5%, 87.9%) to 97.6% (95% CI 93.0%, 98.2%).

conclusionOur results highlight the importance of breastfeeding for infant survival and of ART in reducing the risk of mother-to-child HIV transmission and support the WHO recommendation to initiate ART for life immediately after HIV diagnosis.

Indexed as

Breast FeedingAnti-HIV AgentsChild, PreschoolFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalPregnancyPregnancy Complications, InfectiousSurvival AnalysisAnti-HIV Agentsantiretroviral treatmentARTfemmesHIV-free survivalmujeresrevisión sistemáticarevue systématiquesupervivencia sin VIHsurvie sans VIHsystematic reviewTARwomen

Identifiers

PMID27120500
PMCPMC5096069

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.