Evidence map›Paper›PMID 27120397›Full record

ArticleRedox report : communications in free radical research2017

Restraining reactive oxygen species in Listeria monocytogenes promotes the apoptosis of glial cells.

Sen Li, Yixuan Li, Guowei Chen, Jingchen Zhang, Fei Xu, Man Wu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sen Lia School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Shanghai 200093 , China.
Yixuan Lia School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Shanghai 200093 , China.
Guowei Chena School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Shanghai 200093 , China.
Jingchen Zhangb Certification and Review Center, Shanghai Municipal Food and Drug, Administration , Shanghai 200020 , China.
Fei Xua School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Shanghai 200093 , China.
Man Wua School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology , 516 Jungong Road, Shanghai 200093 , China.
University of Shanghai for Science and Technology · CNShanghai Drug Administration · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesListeria monocytogenes is a facultative anaerobic foodborne pathogen that can traverse the blood-brain barrier and cause brain infection. L. monocytogenes infection induces host cell apoptosis in several cell types. In this study, we investigated the apoptosis of human glioma cell line U251 invaded by L. monocytogenes and evaluated the function of bacterial reactive oxygen species (ROS) during infection.

methodsBacterial ROS level was reduced by carrying out treatment with N-acetyl cysteine (NAC) and diphenyleneiodonium chloride (DPI). After infection, the apoptosis of U251 cells was examined by flow cytometry assay and propidium iodide staining.

resultsDPI and NAC efficiently decreased ROS level in L. monocytogenes without affecting bacterial growth. Moreover, the apoptosis of glial cells was enhanced upon invasion of DPI- and NAC-pretreated L. monocytogenes. DISCUSSION: Results indicate that the apoptosis of glial cells can be induced by L. monocytogenes, and that the inhibition of bacterial ROS increases the apoptosis of host cells.

Indexed as

AcetylcysteineApoptosisCell Line, TumorHumansListeria monocytogenesNeurogliaOnium CompoundsReactive Oxygen SpeciesAcetylcysteinediphenyleneiodoniumOnium CompoundsReactive Oxygen SpeciesApoptosisGlial cellsListeria monocytogenesReactive oxygen species

Identifiers

PMID27120397
PMCPMC6837323
OpenAlexW2343769434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.