Trial reportClinical research in cardiology : official journal of the German Cardiac Society2016
Effects of chronic carotid baroreceptor activation on arterial stiffness in severe heart failure.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Efficacy and safety of baroreflex activation therapy for heart failure with reduced ejection fraction: systematic review.ESC heart failure · 2023Pooled it
- Safety and efficacy of baroreflex activation therapy for heart failure with reduced ejection fraction: a rapid systematic review.ESC heart failure · 2020Pooled it
- Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Trial
- Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Trial
- Beyond Blood Pressure: Arterial Stiffness as a Hemodynamic and Neuroadrenergic Axis Linking Hypertension, Cardiac Remodeling, and Heart Failure.Life (Basel, Switzerland) · 2026Review
- Article
- Heart Rate in Patients with SARS-CoV-2 Infection: Prevalence of High Values at Discharge and Relationship with Disease Severity.Journal of clinical medicine · 2021Article
- Protective Face Masks: Effect on the Oxygenation and Heart Rate Status of Oral Surgeons during Surgery.International journal of environmental research and public health · 2021Article
- Inter-relationships between left ventricular mass, geometry and arterial stiffness.The Journal of international medical research · 2020Article
- Risk of heart failure progression in patients with reduced ejection fraction: mechanisms and therapeutic options.Heart failure reviews · 2020Review
- Influence of Ageing on Vascular Reactivity and Receptor Expression in Rabbit Aorta: A Complement to Elastocalcinosis and Smooth Muscle Mechanisms.Clinical interventions in aging · 2020Article
- Vascular Aging and Disease of the Large Vessels: Role of Inflammation.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Review
- Parameters of pulse wave velocity: determinants and reference values assessed in the population-based study LIFE-Adult.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Aortic Arch Baroreceptor Stimulation in an Experimental Goat Model: A Novel Method to Lower Blood Pressure.Frontiers in cardiovascular medicine · 2018Article
- Restoration of normal sympathetic neural function in heart failure following baroreflex activation therapy: final 43-month study report.Journal of hypertension · 2017Article
- Baroreflex Activation Therapy in Congestive Heart Failure: Novel Findings and Future Insights.Current hypertension reports · 2016Review
- Device Autonomic Regulation Therapy in Patients with Heart Failure with Reduced Ejection Fraction.Journal of atrial fibrillationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart failure with reduced ejection fraction (HFrEF) is characterized by activation of the sympathetic nervous system and increased arterial stiffness, leading to an impaired ventricular-vascular coupling. Baroreflex activation therapy (BAT) has been shown to reduce muscle sympathetic nerve activity (MSNA) and improve clinical status of patients with HFrEF. The purpose of this investigation was to determine the effects of BAT on arterial stiffness in HFrEF. METHODS AND
resultsMSNA, clinical variables, and parameters of central blood pressure (BP) and arterial stiffness were collected in 18 NYHA Class III HFrEF patients, nine receiving BAT and nine continuing with optimal medical management alone. Patients were followed for 3 months, with measurements at that time compared to baseline evaluation. Baseline characteristics of the groups were well matched. At 3 months, BAT did not improve central BP and arterial stiffness despite a significant amelioration of MSNA, NYHA class, Minnesota living with heart failure questionnaire score, number of heart failure medications and six-minute walking distance. The control group exhibited no significant changes in all the measured variables.
conclusionsDespite significant reductions in MSNA and clinical improvement, BAT does not appear to chronically modify arterial stiffness within this HFrEF cohort. Additional study is required to determine if this result applies to the HFrEF population as a whole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.