Evidence map›Paper›PMID 27120289›Full record

ReviewChemical reviews2016

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis.

Markus D Kärkäs, John A Porco, Corey R J Stephenson

Abstract readReview
In one paragraph

Review in Chemical reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Ultrafast Formation of Aza-Quinone Methides from Suitably SubstitutedJournal of the American Chemical Society · 2026
    Article
  7. Review
  8. Review
  9. Role of the Character of the Excited State of Singly Reduced RhJournal of the American Chemical Society · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Short, Enantioselective Total Synthesis of (+)-Ineleganolide.Journal of the American Chemical Society · 2025
    Article
  16. Review
  17. Article
  18. Photochemical access to flavone- and aurone-fused estrone derivatives.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  19. Article
  20. Article

120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Markus D KärkäsDepartment of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.
John A PorcoDepartment of Chemistry, Center for Molecular Discovery (BU-CMD), Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Corey R J StephensonDepartment of Chemistry, University of Michigan , 930 North University Avenue, Ann Arbor, Michigan 48109, United States.

Funding

Chemical Synthesis of Complex Natural Products for Translational ScienceR35GM118173 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI JOHN A. PORCO · 2016 to 2026
$8.2M
Biomimetic Synthesis of Complex Natural ProductsR01GM073855 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PORCO, JOHN A. · 2006 to 2015
$3.2M
Photoredox Catalysis Applications to Bioactive CompoundsR01GM096129 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STEPHENSON, COREY · 2011 to 2015
$1.5M
NIGMS NIH HHS R01 GM073855NIGMS NIH HHS R01 GM096129NIGMS NIH HHS R35 GM118173
6 · The paper itself

Abstract

The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the involvement of electronically excited states, generated upon absorption of photons. This produces transient reactive intermediates and significantly alters the reactivity of a chemical compound. The input of energy provided by light thus offers a means to produce strained and unique target compounds that cannot be assembled using thermal protocols. This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds. Synthetic designs based on photochemical transformations have the potential to afford complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.

Indexed as

Photochemical ProcessesBiological ProductsCycloaddition ReactionBiological Products

Identifiers

PMID27120289
PMCPMC5025835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.