ArticlePloS one2016
A Highly Effective Protocol for the Rapid and Consistent Induction of Digital Dermatitis in Holstein Calves.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 71 citations in OpenAlex.
- An experimental infection model for rapid reproduction of treponeme-associated hoof disease in captive elk (Microbiology spectrum · 2026Article
- Proteolytic dysfunction in bovine digital dermatitis caused by Treponema spp. and the therapeutic use of non-antimicrobial matrix metalloproteinase inhibitors.Communications biology · 2025Article
- Surveillance of hoof disorders in Korean dairy cattle and the correlation of farm condition risk factors to their prevalence.BMC veterinary research · 2025Article
- Bovine Digital Dermatitis: Treponema spp. on trimming equipment and chutes - effect of washing and disinfection.BMC veterinary research · 2024Article
- Proinflammatory CD14Infection and immunity · 2024Article
- 3D Approaches to Culturing Bovine Skin: Explant Culture versus Organotypic Skin Model.Cells, tissues, organs · 2024Article
- Assessment of immunological response to digital dermatitis pathogen derived antigens following infection, recovery, and reinfection.Frontiers in veterinary science · 2024Article
- The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions.Microbiome · 2023Article
- Transmission and lesion progression of treponeme-associated hoof disease in captive elk (Cervus canadensis).PloS one · 2023Article
- An experimental model to induce digital dermatitis in beef calves.BMC veterinary research · 2022Article
- A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions.Infection and immunity · 2021Article
- Tracking Reservoirs of Antimicrobial Resistance Genes in a Complex Microbial Community Using Metagenomic Hi-C: The Case of Bovine Digital Dermatitis.Antibiotics (Basel, Switzerland) · 2021Article
- The dysbiosis of ovine foot microbiome during the development and treatment of contagious ovine digital dermatitis.Animal microbiome · 2021Article
- Lesion Material FromFrontiers in veterinary science · 2021Article
- Article
- Removal of bovine digital dermatitis-associated treponemes from hoof knives after foot-trimming: a disinfection field study.BMC veterinary research · 2020Article
- Putative β-Barrel Outer Membrane Proteins of the Bovine Digital Dermatitis-Associated Treponemes: Identification, Functional Characterization, and Immunogenicity.Infection and immunity · 2020Article
- Article
- Associations between digital dermatitis lesion grades in dairy cattle and the quantities of four Treponema species.Veterinary research · 2018Article
- A Differential Innate Immune Response in Active and Chronic Stages of Bovine Infectious Digital Dermatitis.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine Digital Dermatitis (DD) is a leading cause of lameness in dairy cattle. DD is reportedly increasing in prevalence in beef cattle feedlots of the US. The exact etiologic agent(s) responsible for the disease have yet to be determined. Multiple studies have demonstrated the presence of a variety of Treponema spp. within lesions. Attempts to reproduce clinically relevant disease using pure cultures of these organisms has failed to result in lesions that mirror the morphology and severity of naturally occurring lesions. This manuscript details the systematic development of an experimental protocol that reliably induces digital dermatitis lesions on a large enough scale to allow experimental evaluation of treatment and prevention measures. In total, 21 protocols from five experiments were evaluated on their effectiveness in inducing DD lesions in 126 Holstein calves (504 feet). The protocols varied in the type and concentration of inoculum, frequency of inoculation, duration the feet were wrapped, and type of experimental controls need to validate a successful induction. Knowledge gained in the first four experiments resulted in a final protocol capable of inducing DD lesions in 42 of 44 (95%) feet over a 28 day period. All induced lesions were macroscopically and microscopically identified as clinical DD lesions by individuals blinded to protocols. Lesions were also located at the site of inoculation in the palmer aspect of the interdigital space, and induced clinically measurable lameness in a significant portion of the calves. Collectively these results validate the model and provide a rapid and reliable means of inducing DD in large groups of calves.
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