ArticleGastroenterology research and practice2016
Clinical Features, Diagnosis, and Treatment Strategies of Gastrointestinal Diaphragm Disease Associated with Nonsteroidal Anti-Inflammatory Drugs.
Article in Gastroenterology research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Duodenal Small Bowel Diaphragm Disease: A Rare and Underrecognized Complication of Chronic NSAID Use.ACG case reports journal · 2026Article
- An unexpected finding of large bowel obstruction from colonic diaphragm disease following prolonged use of indomethacin.Journal of surgical case reports · 2026Article
- Article
- Colonic Diaphragmatic Disease: The Concerning Dark Depths of NSAIDs.Digestive diseases and sciences · 2025Review
- Diaphragm Disease of the Terminal Ileum: The Great Imitator.European journal of case reports in internal medicine · 2024Article
- [Computed tomography and magnetic resonance imaging of colonic diseases].Radiologie (Heidelberg, Germany) · 2023Review
- Article
- Article
- Gene expression analysis in NSAID-induced rat small intestinal disease model with the intervention of berberine by the liquid chip technology.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Colonic diaphragm disease secondary to nonsteroidal anti-inflammatory drug use.Proceedings (Baylor University. Medical Center) · 2020Article
- Diaphragm disease of the terminal ileum presenting as acute small bowel obstruction.BMJ case reports · 2020Article
- Small bowel diaphragm disease from long-term non-steroidal anti-inflammatory use.BMJ case reports · 2019Article
- A rare cause of small bowel diaphragm disease presenting with palpated abdominal mass.Journal of surgical case reports · 2019Article
- Jejunal diaphragm disease associated with cytomegalovirus infection.Endoscopy international open · 2019Article
- Nonsteroidal anti-inflammatory drugs induced diaphragm disease: a report of 3 cases and literature review.Annals of surgical treatment and research · 2018Article
- Characteristics of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)-Induced Small Bowel Injury Identified by Single-Balloon Endoscopy or Capsule Endoscopy.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Endoscopy Capsule Retention in a Young Female with Small Bowel Strictures Secondary to Non-Steroidal Anti-Inflammatory Drugs.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. To demonstrate the clinical features, diagnosis, and treatment of nonsteroidal anti-inflammatory drug- (NSAID-) induced diaphragm disease (DD). Methods. A literature search between January 1973 and August 2015 was undertaken. The clinical data of patients with NSAID-induced DD were recorded and analyzed. Results. 159 patients were included. The ratio of male to female was 1 : 2.3; the mean age was 65 ± 11 years. The most common clinical manifestations were gastrointestinal bleeding and obstruction. 121 (84%) patients took traditional NSAIDs. The durations of NSAIDs use ranged from 2 to 300 months. A majority (59.7%) of DD were seen in the small bowel, were seen secondly in the colon (30.2%), and were mainly located in the ileum (57.9%) and right colon (91.7%), respectively. 80% of patients had multiple diaphragms. 41.5% of small bowel DD were diagnosed preoperatively by capsule endoscopy and/or double-balloon enteroscopy, 52.1% at laparotomy. Nearly 75% of patients underwent surgery, endoscopic balloon dilation was performed in 22 patients, and NSAIDs were withdrawn in 53 patients. Conclusions. NSAID-induced DD is relatively rare. The small bowel is most commonly involved. Preoperative diagnosis of small bowel DD is relatively difficult. Discontinuation of the NSAIDs is recommended, surgical resection is the main treatment presently, and endoscopic balloon dilation should be considered as an alternative therapy.
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Registered trials
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