Evidence map›Paper›PMID 27118856›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016

BCG and New Preventive Tuberculosis Vaccines: Implications for Healthcare Workers.

Mark Hatherill, Thomas J Scriba, Zarir F Udwadia, Jai B Mullerpattan, Anthony Hawkridge, Hassan Mahomed, Christopher Dye

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Tuberculosis and Healthcare Workers in Underresourced Settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 5 countries.

Mark HatherillSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.
Zarir F UdwadiaDepartment of Respiratory Medicine, P. D. Hinduja National Hospital, Mumbai, India.
Jai B MullerpattanDepartment of Respiratory Medicine, P. D. Hinduja National Hospital, Mumbai, India.
Anthony HawkridgeDirectorate of Health Impact Assessment, Western Cape Government Department of Health, Cape Town.
Hassan MahomedDivision of Community Health, Faculty of Medicine and Health Sciences, Stellenbosch University Metro District Health Services, Western Cape Government Department of Health, Cape Town, South Africa.
Christopher DyeOffice of the Director General, World Health Organization, Geneva, Switzerland.
University of Cape Town · ZAImpact Assessment · USNational Hospital · INP. D. Hinduja Hospital and Medical Research Centre · INStellenbosch University · ZAWorld Health Organization · CH

Funding

Wellcome TrustWorld Health Organization 001
6 · The paper itself

Abstract

Healthcare workers (HCWs) are at high risk of Mycobacterium tuberculosis (Mtb) infection and tuberculosis disease, but also play a crucial role in implementing healthcare. Preexposure tuberculosis vaccination, including revaccination with BCG, might benefit Mtb-uninfected HCWs, but most HCWs in tuberculosis-endemic countries are already sensitized to mycobacteria. A new postexposure tuberculosis vaccine offers greatest potential for protection, in the setting of repeated occupational Mtb exposure. Novel strategies for induction of mycobacteria-specific resident memory T cells in the lung by aerosol administration, or induction of T cells with inherent propensity for residing in mucosal sites, such as CD1-restricted T cells and mucosa-associated innate T cells, should be explored. The need for improved protection of HCWs against tuberculosis disease is clear. However, health systems in tuberculosis-endemic countries would need significantly improved occupational health structures to implement a screening and vaccination strategy for HCWs.

Indexed as

BCG VaccineHealth PersonnelOccupational DiseasesTuberculosisTuberculosis VaccinesHumansOccupational ExposureSouth AfricaBCG VaccineTuberculosis Vaccineshealthcare workerspreventiontuberculosisvaccine

Identifiers

PMID27118856
PMCPMC4845890
OpenAlexW2343415728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.