ReviewInternational journal of epidemiology2016
Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks.
Review in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Investigating targeted and untargeted approaches to biomarker discovery in fearful, adult dogs.Journal of animal science · 2026Article
- Cumulative burden and dynamic trajectories of heart rate as predictors of prognosis in acute pancreatitis: an 18-year cohort study.International journal of surgery (London, England) · 2026Article
- Technical Report: A Comprehensive Comparison between Different Quantification Versions of Nightingale Health'sMetabolites · 2023Article
- Trends in Population-Based Studies: Molecular and Digital Epidemiology (Review).Sovremennye tekhnologii v meditsine · 2022Review
- Integrated 16S rDNA Gene Sequencing and Untargeted Metabolomics Analyses to Investigate the Gut Microbial Composition and Plasma Metabolic Phenotype in Calves With Dampness-Heat Diarrhea.Frontiers in veterinary science · 2022Article
- Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle approach.Environment international · 2022Article
- Pharmaco-metabolomics opportunities in drug development and clinical research.Analytical science advances · 2021Article
- Opportunities for Gene and Environment Research in Cancer: An Updated Review of NCI's Extramural Grant Portfolio.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Review
- Current Concepts in Pharmacometabolomics, Biomarker Discovery, and Precision Medicine.Metabolites · 2020Review
- Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine.Metabolites · 2020Review
- Application of metabolomics to characterize environmental pollutant toxicity and disease risks.Reviews on environmental health · 2019Review
- Metabolomic correlates of central adiposity and earlier-life body mass index.Journal of lipid research · 2019Article
- Review of recent developments in GC-MS approaches to metabolomics-based research.Metabolomics : Official journal of the Metabolomic Society · 2018Review
- Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Integrating -Omics Approaches into Human Population-Based Studies of Prenatal and Early-Life Exposures.Current environmental health reports · 2018Review
- Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance.Scientific reports · 2018Article
- Machine learning approaches to the social determinants of health in the health and retirement study.SSM - population health · 2018Article
- Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women.Frontiers in public health · 2018Article
- A Serum Small Molecule Biosignature of Radiation Exposure from Total Body Irradiated Patients.Journal of proteome research · 2017Article
- Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches.Respiratory medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics is becoming feasible for population-scale studies of human disease. In this review, we survey epidemiological studies that leverage metabolomics and multi-omics to gain insight into disease mechanisms. We outline key practical, technological and analytical limitations while also highlighting recent successes in integrating these data. The use of multi-omics to infer reaction rates is discussed as a potential future direction for metabolomics research, as a means of identifying biomarkers as well as inferring causality. Furthermore, we highlight established analysis approaches as well as simulation-based methods currently used in single- and multi-cell levels in systems biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.