Evidence map›Paper›PMID 27118443›Full record

SynthesisJournal of the International AIDS Society2016

A systematic review of interventions to improve postpartum retention of women in PMTCT and ART care.

Pascal Geldsetzer, H Manisha N Yapa, Maria Vaikath, Osondu Ogbuoji, Matthew P Fox, Shaffiq M Essajee, Eyerusalem K Negussie, Till Bärnighausen

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the International AIDS Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03058484 (Short-term Effectiveness of a Community Health Worker Intervention for HIV-infected Pregnant Women in Tanzania to Improve Treatment Adherence and Retention in Care), which is not on this map. Cited by 89 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03058484 nacompletednot on this map

Short-term Effectiveness of a Community Health Worker Intervention for HIV-infected Pregnant Women in Tanzania to Improve Treatment Adherence and Retention in Care: A Cluster-Randomized Trial

TypeinterventionalSponsorUniversity of California, BerkeleyRan2015 to 2016Enrolled1,830ConditionsVertical Transmission of Infectious Disease, HIV InfectionsArmsCommunity Health Worker intervention
3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pascal GeldsetzerDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA; pag395@mail.harvard.edu.
H Manisha N YapaAfrica Centre for Population Health, University of KwaZulu Natal, Mtubatuba, South Africa.
Maria VaikathDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Osondu OgbuojiDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Matthew P FoxCenter for Global Health & Development, Boston University, Boston, MA, USA.
Shaffiq M EssajeeHIV/AIDS Department, World Health Organization, Geneva, Switzerland.
Eyerusalem K NegussieHIV/AIDS Department, World Health Organization, Geneva, Switzerland.
Till BärnighausenDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Funding

Causal Pathways to population health impact of HIV antiretroviral treatmentR01HD084233 · NICHD · UNIVERSITY OF KWAZULU-NATAL · PI BARNIGHAUSEN, TILL, TANSER, FRANK COURTENEY · 2015 to 2021
$2.3M
NICHD NIH HHS R01 HD084233World Health Organization 001
6 · The paper itself

Abstract

introductionThe World Health Organization recommends lifelong antiretroviral therapy (ART) for all pregnant and breastfeeding women living with HIV. Effective transitioning from maternal and child health to ART services, and long-term retention in ART care postpartum is crucial to the successful implementation of lifelong ART for pregnant women. This systematic review aims to determine which interventions improve (1) retention within prevention of mother-to-child HIV transmission (PMTCT) programmes after birth, (2) transitioning from PMTCT to general ART programmes in the postpartum period, and (3) retention of postpartum women in general ART programmes.

methodsWe searched Medline, Embase, ISI Web of Knowledge, the regional World Health Organization databases and conference abstracts for data published between 2002 and 2015. The quality of all included studies was assessed using the GRADE criteria. RESULTS AND DISCUSSION: After screening 8324 records, we identified ten studies for inclusion in this review, all of which were from sub-Saharan Africa except for one from the United Kingdom. Two randomized trials found that phone calls and/or text messages improved early (six to ten weeks) postpartum retention in PMTCT. One cluster-randomized trial and three cohort studies found an inconsistent impact of different levels of integration between antenatal care/PMTCT and ART care on postpartum retention. The inconsistent results of the four identified studies on care integration are likely due to low study quality, and heterogeneity in intervention design and outcome measures. Several randomized trials on postpartum retention in HIV care are currently under way.

conclusionsOverall, the evidence base for interventions to improve postpartum retention in HIV care is weak. Nevertheless, there is some evidence that phone-based interventions can improve retention in PMTCT in the first one to three months postpartum.

Indexed as

Anti-HIV AgentsFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalPostpartum PeriodPregnancyWorld Health OrganizationAnti-HIV Agentsantiretroviral therapyHIVloss to follow-upOption B+PMTCTpostpartumretention

Identifiers

PMID27118443
PMCPMC4846797

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.