ArticleAnnals of epidemiology2016
Impact of age and sex on the composition and abundance of the intestinal microbiota in individuals with and without enteric infections.
Article in Annals of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effect of Prebiotics and Probiotics on Levels of Depression, Anxiety, and Cognitive Function: A Meta-Analysis of Randomized Clinical Trials.Brain and behavior · 2025Pooled it
- Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis.BMC psychiatry · 2023Pooled it
- Comparing gut resistome composition among patients with acute Campylobacter infections and healthy family members.Scientific reports · 2021Trial
- Sex differences in the gut microbiome and related metabolites: role in cardiometabolic disease.Gut microbes · 2026Review
- Article
- High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner.European journal of nutrition · 2026Article
- Gut Microbial Diversity and Community Structure Are Largely Similar Between Apparently Healthy Elderly Japanese Males and Females: A Shotgun Metagenomic Study.Life (Basel, Switzerland) · 2026Article
- The role of gut microbiome in the pathophysiology of PTSD, depression, and anxiety disorders.Gut microbes reports · 2026Review
- Article
- Comparative Analyses of Gut Microbiomes inEcology and evolution · 2025Article
- Global burden, subtype, risk factors and etiological analysis of enteric infections from 1990-2021: population based study.Frontiers in cellular and infection microbiology · 2025Article
- The influence of sex-specific factors on biological transformations and health outcomes in aging processes.Biogerontology · 2024Review
- Do high-protein diets have the potential to reduce gut barrier function in a sex-dependent manner?European journal of nutrition · 2024Article
- Sex and Gender Differences in Alzheimer's Disease: Genetic, Hormonal, and Inflammation Impacts.International journal of molecular sciences · 2024Review
- Effects of ultra-processed foods on the liver: insights from gut microbiome and metabolomics studies in rats.Frontiers in nutrition · 2024Article
- Shifts in the functional capacity and metabolite composition of the gut microbiome during recovery from enteric infection.Frontiers in cellular and infection microbiology · 2024Article
- Heterogeneity of gut microbiome compositions in the third decade of life in Japanese women: insights from a comparative analysis.Bioscience of microbiota, food and health · 2024Article
- Estrobolome and Hepatocellular Adenomas-Connecting the Dots of the Gut Microbial β-Glucuronidase Pathway as a Metabolic Link.International journal of molecular sciences · 2023Review
- Recovery of the gut microbiome following enteric infection and persistence of antimicrobial resistance genes in specific microbial hosts.Scientific reports · 2023Article
- Microbiota Profiling on Veterinary Faculty Restroom Surfaces and Source Tracking.Microorganisms · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
purposeThe intestinal microbiome is critical for human health and preventing colonization by enteric pathogens. There are notable differences in the microbiota composition among individuals with and without enteric infections, though the impact that age and gender has on the composition and abundance of intestinal microbes is not known.
methodsA comparative 16S rRNA gene sequencing study was performed on stool DNA from 200 patients with enteric infections and 75 healthy family members representing both sexes and multiple age groups.
resultsMicrobial community profiles were affected by age and sex in patients with enteric infections and their healthy family members. Overall, we observed an increase in Bacteroides abundance and decrease in Escherichia abundance with age, though these differences were most apparent for patients with enteric infections. Genus Bacteroides was also higher in female communities while Escherichia predominated in males.
conclusionsBecause Escherichia abundance was previously linked to symptom severity, children with enteric infections may be most susceptible to severe disease outcomes due to high and low abundance of Escherichia and Bacteroides, respectively. Future studies should focus on classifying specific differences in the microbiome using metagenomics and identifying novel methods aimed at shifting the intestinal microbiome to a healthy state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.