Evidence map›Paper›PMID 27118196›Full record

ArticleEuropean heart journal2017

Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations.

Derek J Hausenloy, Hans Erik Botker, Thomas Engstrom, David Erlinge, Gerd Heusch, Borja Ibanez, Robert A Kloner, Michel Ovize, Derek M Yellon, David Garcia-Dorado

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04912518 (Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction), which is not on this map. Cited by 170 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04912518 narecruitingnot on this mapstarted 2021, after this paper: background citation

Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction: a Double-Blind, Multicenter, Randomized, Placebo-Controlled Clinical Trial

TypeinterventionalSponsorHarbin Medical UniversityRan2021 to 2025Enrolled250ConditionsST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention, CardioprotectionArmsDexmedetomidine (DEX), Placebo (Saline)
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Guidelines for experimental models of myocardial ischemia and infarction.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. ETS‑1/ETS‑2 transcription factors in CVD (Review).International journal of molecular medicine · 2026
    Review
  20. Article

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Derek J HausenloyCardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.
Hans Erik BotkerDepartment of Cardiology, Aarhus University Hospital Skejby, DK-8200 Aarhus N, Denmark.
Thomas EngstromDepartment of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
David ErlingeDepartment of Cardiology, Lund University, Lund, Sweden.
Gerd HeuschInstitute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.
Borja IbanezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Robert A KlonerHuntington Medical Research Institutes, Pasadena, CA, USA.
Michel OvizeExplorations Fonctionnelles Cardiovasculaires, Hôpital Louis Pradel, Lyon, France.
Derek M YellonThe Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK.
David Garcia-DoradoDepartment of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autònoma, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenosineCardiotonic AgentsClinical Trials as TopicCombined Modality TherapyCoronary VesselsCyclosporineEnzyme InhibitorsHumansHypothermia, InducedIschemic PostconditioningMetoprololMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMyocardial ReperfusionMyocardial Reperfusion InjuryNitric Oxide3,5-seco-4-norcholestan-5-one oxime-3-olAdenosinearginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamideCardiotonic Agentscyclic guanosine monophosphate-adenosine monophosphateCyclosporineEnzyme InhibitorsMetoprololMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreNitric OxideNitritesNucleotides, CyclicOligopeptidesOximesProtein Kinase CSecosteroidsVasodilator Agents

Identifiers

PMID27118196
PMCPMC5381598

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.