ArticleNature communications2016
Homotypic cell competition regulates proliferation and tiling of zebrafish pigment cells during colour pattern formation.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Winners take it all: turning cell competition into a therapeutic ally.Cell communication and signaling : CCS · 2026Review
- Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis.PLoS genetics · 2025Article
- Linking discrete and continuous models of cell birth and migration.Royal Society open science · 2024Article
- A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots.PLoS genetics · 2021Article
- Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish.Nature communications · 2020Article
- Article
- Topological data analysis of zebrafish patterns.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Insights Into the Albinism Mechanism for Two Distinct Color Morphs of Northern Snakehead,Frontiers in genetics · 2020Article
- Multicolor lineage tracing using in vivo time-lapse imaging reveals coordinated death of clonally related cells in the developing vertebrate brain.Developmental biology · 2019Article
- The identification of genes involved in the evolution of color patterns in fish.Current opinion in genetics & development · 2019Review
- Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio).BMC genomics · 2019Article
- Iridophores as a source of robustness in zebrafish stripes and variability in Danio patterns.Nature communications · 2018Article
- Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2.Developmental cell · 2018Article
- ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Self-organizing spots get under your skin.PLoS biology · 2017Review
- Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment.Development (Cambridge, England) · 2017Article
- Mechanisms and in vivo functions of contact inhibition of locomotion.Nature reviews. Molecular cell biology · 2017Review
- Article
- Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish.Biology open · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adult striped pattern of zebrafish is composed of melanophores, iridophores and xanthophores arranged in superimposed layers in the skin. Previous studies have revealed that the assembly of pigment cells into stripes involves heterotypic interactions between all three chromatophore types. Here we investigate the role of homotypic interactions between cells of the same chromatophore type. Introduction of labelled progenitors into mutants lacking the corresponding cell type allowed us to define the impact of competitive interactions via long-term in vivo imaging. In the absence of endogenous cells, transplanted iridophores and xanthophores show an increased rate of proliferation and spread as a coherent net into vacant space. By contrast, melanophores have a limited capacity to spread in the skin even in the absence of competing endogenous cells. Our study reveals a key role for homotypic competitive interactions in determining number, direction of migration and individual spacing of cells within chromatophore populations.
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Registered trials
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