ArticleStem cell reports2016
A Subpopulation of Label-Retaining Cells of the Kidney Papilla Regenerates Injured Kidney Medullary Tubules.
Article in Stem cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Urine-derived stem cells in kidney disease: progress, challenges, and future directions.Stem cell research & therapy · 2026Review
- Lineage tracing reveals KSPFrontiers in cell and developmental biology · 2026Article
- Fewer medullary pyramids in the living kidney donor are associated with graft failure in the recipient.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Regenerative Role of Lrig1+ Cells in Kidney Repair.Journal of the American Society of Nephrology : JASN · 2024Article
- Reduced urine volume and changed renal sphingolipid metabolism in P2ry14-deficient mice.Frontiers in cell and developmental biology · 2023Article
- Age-Associated Loss in Renal Nestin-Positive Progenitor Cells.International journal of molecular sciences · 2022Article
- Article
- Potential renal stem/progenitor cells identified by in vivo lineage tracing.American journal of physiology. Renal physiology · 2022Review
- Identification of a foetal epigenetic compartment in adult human kidney.Epigenetics · 2022Article
- Regenerative medicine therapies: lessons from the kidney.Current opinion in physiology · 2020Review
- Kidney Cells Regeneration: Dedifferentiation of Tubular Epithelium, Resident Stem Cells and Possible Niches for Renal Progenitors.International journal of molecular sciences · 2019Review
- Kidney-Derived c-KitStem cells translational medicine · 2018Article
- Highly tamoxifen-inducible principal cell-specific Cre mice with complete fidelity in cell specificity and no leakiness.American journal of physiology. Renal physiology · 2018Article
- Isolation and Characterization of Multipotent CD24+ Cells From the Renal Papilla of Swine.Frontiers in medicine · 2018Article
- Biomarker discovery for renal cancer stem cells.The journal of pathology. Clinical research · 2018Review
- Comparing adult renal stem cell identification, characterization and applications.Journal of biomedical science · 2017Review
- Fatty acid synthase cooperates with protrudin to facilitate membrane outgrowth of cellular protrusions.Scientific reports · 2017Article
- Cellular plasticity in kidney injury and repair.Nature reviews. Nephrology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
To determine whether adult kidney papillary label-retaining cells (pLRCs) are specialized precursors, we analyzed their transcription profile. Among genes overexpressed in pLRCs, we selected candidate genes to perform qPCR and immunodetection of their encoded proteins. We found that Zfyve27, which encodes protrudin, identified a subpopulation of pLRCs. With Zfyve27-CreERT2 transgenic and reporter mice we generated bitransgenic animals and performed cell-lineage analysis. Post tamoxifen, Zfyve27-CreERT2 marked cells preferentially located in the upper part of the papilla. These cells were low cycling and did not generate progeny even after long-term observation, thus they did not appear to contribute to kidney homeostasis. However, after kidney injury, but only if severe, they activated a program of proliferation, migration, and morphogenesis generating multiple and long tubular segments. Remarkably these regenerated tubules were located preferentially in the kidney medulla, indicating that repair of injury in the kidney is regionally specified. These results suggest that different parts of the kidney have different progenitor cell pools.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.