Evidence map›Paper›PMID 27117709›Full record

ArticleNature communications2016

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.

Fergus J Couch, Karoline B Kuchenbaecker, Kyriaki Michailidou, Gustavo A Mendoza-Fandino, Silje Nord, Janna Lilyquist, Curtis Olswold, Emily Hallberg, Simona Agata, Habibul Ahsan and 239 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 5 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 5 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Review
  8. Article
  9. Review
  10. Targeting Oestrogen Receptor Signalling in Breast Cancer Therapy.Advances in experimental medicine and biology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. bioRxiv : the preprint server for biology · 2023
    Article
  15. Review
  16. Aging · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

249 authors at 20 institutions in 33 countries.

Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Karoline B KuchenbaeckerCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Gustavo A Mendoza-FandinoCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
Silje NordDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway.
Janna LilyquistDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Curtis OlswoldDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Emily HallbergDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Simona AgataImmunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, 20133 Padua, Italy.
Habibul AhsanDepartment of Health Studies, The University of Chicago, Chicago, Illinois 60637, USA.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Central Hospital, 00029 Helsinki, Finland.
Christine AmbrosoneDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Irene L AndrulisLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Hoda Anton-CulverDepartment of Epidemiology, University of California Irvine, Irvine, California, 92697, USA.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Banu K ArunUniversity of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Brita ArverDepartment of Oncology, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Monica BarileDivision of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, 20141 Milan, Italy.
Rosa B BarkardottirDepartment of Pathology, Landspitali University Hospital and University of Iceland School of Medicine, 101 Reykjavik, Iceland.
Daniel BarrowdaleCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Lars BeckmannInstitute for Quality and Efficiency in Health Care (IQWiG), 50670 Cologne, Germany.
Matthias W BeckmannUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Javier BenitezHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.
Stephanie V BlankNYU Women's Cancer Program, New York University School of Medicine, New York, New York 10016, USA.
Carl BlomqvistDepartment of Oncology, University of Helsinki and Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
Natalia V BogdanovaDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany.
Stig E BojesenCopenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Bernardo BonanniDivision of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, 20141 Milan, Italy.
Hiltrud BrauchDr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Barbara BurwinkelDepartment of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
Saundra S BuysDepartment of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City Utah 84112, USA.
Trinidad CaldesMolecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid 28040, Spain.
Maria A CaligoSection of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, I-56126 Pisa, Italy.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Jane CarpenterAustralian Breast Cancer Tissue Bank, Westmead Millennium Institute, University of Sydney, Sydney, New South Wales 2145, Australia.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, USA.
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University, New York, New York 10032, USA.
Kathleen B M ClaesCenter for Medical Genetics, Ghent University, 9000 Ghent, Belgium.
Angela CoxSheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK.
Simon S CrossAcademic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Francesca DamiolaINSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, 69373 Lyon, France.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Miguel de la HoyaMolecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid 28040, Spain.
Peter DevileeDepartment of Human Genetics and Department of Pathology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands.
Orland DiezOncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, 08035 Barcelona, Spain.
Yuan C DingDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Riccardo DolcettiCancer Bioimmunotherapy Unit, CRO Aviano National Cancer Institute, 33081 Aviano , Italy.
Susan M DomchekAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA.
Cecilia M DorflingDepartment of Genetics, University of Pretoria, Pretoria 0007, South Africa.
Isabel Dos-Santos-SilvaDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Martine DumontCancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada G1V 4G2.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Diana M EcclesFaculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, Hampshire SO16 6YD, UK.
Hans EhrencronaDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala SE-751 85, Sweden.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Heather EliassenChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Steve EllisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Peter A FaschingUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Jonine FigueroaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, USA.
Dieter Flesch-JanysDepartment of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany.
Asta FörstiDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Florentia FostiraMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, 15310 Athens, Greece.
William D FoulkesProgram in Cancer Genetics, McGill University, Montreal, Quebec, Canada H3A 0G4.
Tara FriebelUniversity of, Philadelphia, Pennsylvania 19104, USA.
Eitan FriedmanSusanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer 52621, Israel.
Debra FrostCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Marike GabrielsonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Marilie D GammonDepartment of Epidemiology, University of, Chapel Hill, North Carolina 27599-7400, USA.
Patricia A GanzUCLA Schools of Medicine and Public Health, Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Los Angeles, California 90095-6900, USA.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Judy GarberCancer Risk and Prevention Clinic, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Mia M GaudetEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Simon A GaytherDepartment of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California 90048, USA.
Anne-Marie GerdesDepartment of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Maya GhoussainiCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3010, Australia.
Gord GlendonLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Andrew K GodwinDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, 66205, USA.
Mark S GoldbergDepartment of Medicine, McGill University, Montreal, Quebec, Canada H3G 2M1.
David E GoldgarDepartment of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
Anna González-NeiraHuman Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Mark H GreeneClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850-9772, USA.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Pascal GuénelInserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 70-115 Villejuif, France.
Marc GunterDepartment of of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, SW7 2AZ, UK.
Lothar HaeberleUniversity Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Thomas V O HansenCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.
Steven HartDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Sue HealeyDepartment of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Tuomas HeikkinenDepartment of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Josef HerzogClinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California 91010, USA.
Frans B L HogervorstFamily Cancer Clinic, Netherlands Cancer Institute, Amsterdam 1000 BE, The Netherlands.
Antoinette HollestelleDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam 3008 AE, The Netherlands.
Maartje J HooningDepartment of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam 3008 AE, The Netherlands.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20850, USA.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Keith HumphreysDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
David J HunterProgram in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Tomasz HuzarskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Evgeny N ImyanitovN.N. Petrov Institute of Oncology, 197758 St Petersburg, Russia.
Claudine IsaacsLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Paul JamesFamilial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria 8006, Australia.
Ramunas JanaviciusState Research Institute Centre for Innovative Medicine, LT-08661 Vilnius, Lithuania.
Uffe Birk JensenDepartment of Clinical Genetics, Aarhus University Hospital, 8200 Aarhus N, Denmark.
Esther M JohnDepartment of Epidemiology, Cancer Prevention Institute of California, Fremont, California 94538, USA.
Michael JonesDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK.
Maria KabischMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Siddhartha KarCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
Sofia KhanDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
Muhammad G KibriyaDepartment of Health Studies, The University of Chicago, Chicago, Illinois 60637, USA.
Julia A KnightProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
Yon-Dschun KoDepartment of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, 53113 Bonn, Germany.
Irene KonstantopoulouMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, 15310 Athens, Greece.
Veli-Matti KosmaSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Vessela KristensenDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway.
Ava KwongThe Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong.
Yael LaitmanSusanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer 52621, Israel.
Diether LambrechtsVesalius Research Center, VIB, 3000 Leuven, Belgium.
Conxi LazaroMolecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, 08908 Barcelona, Spain.
Eunjung LeeDepartment of Preventive Medicine, University of Southern California, Los Angeles, California 90032, USA.
Loic Le MarchandCancer Epidemiology Program, University of Cancer Center, Honolulu, Hawaii 96813, USA.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Noralane LindorHealth Sciences Research, Mayo Clinic, Scotsdale, Arizona 85259, USA.
Sara LindstromDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Jianjun LiuHuman Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Phuong L MaiClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850-9772, USA.
Enes MakalicCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Kathleen E MaloneDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Arto MannermaaSchool of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland.
Siranoush ManoukianUnit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), 20133 Milan, Italy.
Sara MargolinDepartment of Oncology, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Frederik MarmeDepartment of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
John W M MartensDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam 3008 AE, The Netherlands.
Lesley McGuffogCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Alfons MeindlDepartment of Gynaecology and Obstetrics, Technical University of Munich, 81675 Munich, Germany.
Austin MillerNRG Oncology Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3010, Australia.
Penelope MironDepartment of Genomics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA.
Marco MontagnaImmunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, 20133 Padua, Italy.
Sylvie MazoyerINSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, 69373 Lyon, France.
Anna M MulliganLaboratory Medicine Program, University Health Network, Toronto, Ontario, Canada M5B 1W8.
Taru A MuranenDepartment of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
Katherine L NathansonAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, FI-00029 Helsinki, Finland.
Børge G NordestgaardCopenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark.
Robert L NussbaumInvitae Corporation, San Francisco, California 94107, USA.
Kenneth OffitDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Edith OlahDepartment of Molecular Genetics, National Institute of Oncology, H-1122 Budapest, Hungary.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois 60637, USA.
Janet E OlsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Ana OsorioHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), 28029 Madrid, Spain.
Sue K ParkDepartment of Preventive Medicine and Biomedical Science, Seoul National University College of Medicine and Cancer Research Institute, Seoul National University, 110-799 Seoul, Republic of Korea.
Petra H PeetersDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht 3508 GA, The Netherlands.
Bernard PeisselUnit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), 20133 Milan, Italy.
Paolo PeterlongoIFOM, Fondazione Istituto FIRC di Oncologia Molecolare, 20133 Milan, Italy.
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Catherine M PhelanCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
Robert PilarskiDivison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.
Bruce PoppeCenter for Medical Genetics, Ghent University, 9000 Ghent, Belgium.
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, FI-90220 Oulu, Finland.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), 20133 Milan, Italy.
Nazneen RahmanSection of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK.
Johanna RantalaDepartment of Clinical Genetics, Karolinska University Hospital, SE-17176 Stockholm, Sweden.
Christine RappaportDepartment of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, A 1090 Vienna, Austria.
Gad RennertClalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa 34362, Israel.
Andrea RichardsonDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA.
Mark RobsonDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Isabelle RomieuInternational Agency for Research on Cancer, 69008 Lyon, France.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Emiel J RutgersNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam 1006 BE, The Netherlands.
Maria-Jose SanchezEscuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, 18014 Granada, Spain.
Regina M SantellaDepartment of Environmental Health Sciences, Columbia University, New York, New York, 10032, USA.
Elinor J SawyerResearch Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, London SE1 9RT, UK.
Daniel F SchmidtCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Marjanka K SchmidtNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam 1006 BE, The Netherlands.
Rita K SchmutzlerCenter for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne 50931, Germany.
Fredrick SchumacherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
Rodney ScottDivision of Genetics, Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales 2305, Australia.
Leigha SenterDivison of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.
Priyanka SharmaDepartment of Hematology and Oncology, University of Kansas Medical Center, Kansas City, Kansas 66205, USA.
Jacques SimardCentre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Quebec, Canada G1V 4G2.
Christian F SingerDepartment of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, A 1090 Vienna, Austria.
Olga M SinilnikovaINSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, 69373 Lyon, France.
Penny SoucyCentre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Quebec, Canada G1V 4G2.
Melissa SoutheyDepartment of Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
Doris SteinemannHannover Medical School, 30625 Hannover, Germany.
Marie Stenmark-AskmalmDivision of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, SE-58185 Linköping, Sweden.
Dominique Stoppa-LyonnetInstitut Curie, Department of Tumour Biology, 75248 Paris, France.
Anthony SwerdlowDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton SM2 5NG, UK.
Csilla I SzaboNational Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-2152, USA.
Rulla TamimiChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
William TapperFaculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, Hampshire SO16 6YD, UK.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute, Porto, 4200-072, Portugal.
Soo-Hwang TeoCancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya 47500, Malaysia.
Mary B TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, 10032, USA.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, 5000 Odense C, Denmark.
Deborah ThompsonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Laima TihomirovaLatvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia.
Amanda E TolandDepartment of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, 43210, USA.
Robert A E M TollenaarDepartment of Surgical Oncology, Leiden University Medical Center, Leiden 2333 ZC, The Netherlands.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
Thérèse TruongInserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 70-115 Villejuif, France.
Helen TsimiklisDepartment of Pathology, The University of Melbourne, Melbourne, Victoria, Australia.
Alex TeuléGenetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, 08908 Barcelona, Spain.
Rosario TuminoCancer Registry and Histopathology Unit, 'Civic-M.P. Arezzo' Hospital, 97100 ASP Ragusa, Italy.
Nadine TungDepartment of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA.
Clare TurnbullSection of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK.
Giski UrsinCancer Registry of Norway, Institute of Population-Based Cancer Research, N-0304 Oslo, Norway.
Carolien H M van DeurzenDepartment of Pathology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands.
Elizabeth J van RensburgDepartment of Genetics, University of Pretoria, Pretoria 0007, South Africa.
Raymonda Varon-MateevaInstitute of Human Genetics, Charite Berlin, 13353 Berlin, Germany.
Zhaoming WangCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
Shan Wang-GohrkeUniversity Hospital Ulm, 89075 Ulm, , Germany.
Elisabete WeiderpassDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Jeffrey N WeitzelClinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California 91010, USA.
Alice WhittemoreDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California 94305, USA.
Hans WildiersMultidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals, B-3000 Leuven, Belgium.
Robert WinqvistLaboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, FI-90220 Oulu, Finland.
Xiaohong R YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Drakoulis YannoukakosMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, 15310 Athens, Greece.
Song YaoDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
M Pilar ZamoraServicio de Oncología Médica, Hospital Universitario La Paz, 28046 Madrid, Spain.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Peter KraftDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Celine VachonDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Susan SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Georgia Chenevix-TrenchCancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
Alvaro A N MonteiroCancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
Montserrat García-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20850, USA.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
University of Cambridge · GBGerman Cancer Research Center · DEKarolinska Institutet · SEMayo Clinic in Florida · USThe University of Melbourne · AUNational Cancer Institute · USHeidelberg University · DEInstitute of Cancer Research · GBNational Institutes of Health · USPomeranian Medical University · PLUniversity of Southern California · USCedars-Sinai Medical Center · USCentre hospitalier universitaire de Québec · CAColumbia University · USFondazione IRCCS Istituto Nazionale dei Tumori · ITHarvard University · USKarolinska University Hospital · SEMoffitt Cancer Center · USMount Sinai Hospital · CANational Centre of Scientific Research "Demokritos" · GR

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
NRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5M
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI Fergus Joseph Couch · 2005 to 2026
$49.9M
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
NRG Oncology Biospecimen BankU24CA196067 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Tanner J. Freeman, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$42.6M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 11174Cancer Research UK 14136Cancer Research UK 16561Cancer Research UK 16565Cancer Research UK 19187Medical Research Council G0401527Medical Research Council G0700491Medical Research Council MC_PC_14105Medical Research Council MR/N003284/1NCI NIH HHS P30 CA006927NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA116201NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA176785NCI NIH HHS R01 CA192393NCI NIH HHS R25 CA092049NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA116167NCI NIH HHS U10 CA180868NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS U24 CA196067NCI NIH HHS UG1 CA189867NIEHS NIH HHS P30 ES009089Wellcome TrustWorld Health Organization 001
6 · The paper itself

Abstract

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.

Indexed as

BRCA1 ProteinBreast NeoplasmsChromosomes, Human, Pair 2CyclophilinsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHeterozygoteHumansMutationPolymorphism, Single NucleotideReceptors, EstrogenRisk FactorstRNA MethyltransferasesBRCA1 ProteinBRCA1 protein, humanCyclophilinsPPIL3 protein, humanReceptors, EstrogenTrmt61B protein, humantRNA Methyltransferases

Identifiers

PMID27117709
PMCPMC4853421
OpenAlexW2339358896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.