ReviewSeminars in immunology2015
Macrophages and cellular immunity in Drosophila melanogaster.
Review in Seminars in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 150 citations in OpenAlex.
- Multiple evolutionary routes to immune diversification across animals.International immunology · 2026Review
- Metal Oxide Doping Modulates the Performances of Copper Oxide Nanoparticular Biocides.Nanomaterials (Basel, Switzerland) · 2026Article
- Recent insights in the development and functions of insect hemocytes.Current opinion in insect science · 2026Review
- Zika virus infection reduces hemocyte numbers and induces hemocyte aggregation in adultmicroPublication biology · 2026Article
- Article
- Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood-brain barrier.PLoS biology · 2025Article
- Juvenile hormone mimics induce a cellular immune response inmicroPublication biology · 2025Article
- Drosophila as a Model for Metastasis.Advances in experimental medicine and biology · 2025Review
- Macrophage-like Blood Cells Are Involved in Inter-Tissue Communication to Activate JAK/STAT Signaling, Inducing Antitumor Turandot Proteins inInternational journal of molecular sciences · 2024Article
- Adhesive and mechanical properties of the glue produced by 25 Drosophila species.Scientific reports · 2024Article
- Dysregulation of innate immune signaling in animal models of spinal muscular atrophy.BMC biology · 2024Article
- Using Drosophila to uncover the role of organismal physiology and the tumor microenvironment in cancer.Trends in cancer · 2024Review
- Senescent cells and macrophages cooperate through a multi-kinase signaling network to promote intestinal transformation in Drosophila.Developmental cell · 2024Article
- Dysregulation of innate immune signaling in animal models of Spinal Muscular Atrophy.bioRxiv : the preprint server for biology · 2023Article
- Mitochondrial metabolism in Drosophila macrophage-like cells regulates body growth via modulation of cytokine and insulin signaling.Biology open · 2023Article
- Delayed host mortality and immune response upon infection withInfection and immunity · 2023Article
- The macrophage genetic cassetteScience advances · 2023Article
- Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis.Development (Cambridge, England) · 2023Article
- Tissue-specific macrophages: how they develop and choreograph tissue biology.Nature reviews. Immunology · 2023Review
- Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The invertebrate Drosophila melanogaster has been a powerful model for understanding blood cell development and immunity. Drosophila is a holometabolous insect, which transitions through a series of life stages from embryo, larva and pupa to adulthood. In spite of this, remarkable parallels exist between Drosophila and vertebrate macrophages, both in terms of development and function. More than 90% of Drosophila blood cells (hemocytes) are macrophages (plasmatocytes), making this highly tractable genetic system attractive for studying a variety of questions in macrophage biology. In vertebrates, recent findings revealed that macrophages have two independent origins: self-renewing macrophages, which reside and proliferate in local microenvironments in a variety of tissues, and macrophages of the monocyte lineage, which derive from hematopoietic stem or progenitor cells. Like vertebrates, Drosophila possesses two macrophage lineages with a conserved dual ontogeny. These parallels allow us to take advantage of the Drosophila model when investigating macrophage lineage specification, maintenance and amplification, and the induction of macrophages and their progenitors by local microenvironments and systemic cues. Beyond macrophage development, Drosophila further serves as a paradigm for understanding the mechanisms underlying macrophage function and cellular immunity in infection, tissue homeostasis and cancer, throughout development and adult life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.