Evidence map›Paper›PMID 27117455›Full record

Trial reportBMC pulmonary medicine2016

Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis: a randomised pilot trial.

Daniel Franzen, Andreas H Diacon, Lutz Freitag, Pawel T Schubert, Colleen A Wright, Macé M Schuurmans

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pulmonary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02490059 (Ultrathin Bronchoscopy for Solitary Pulmonary Nodules), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02490059 phase4completednot on this map

Ultrathin Bronchoscopy for Solitary Pulmonary Nodules: A Randomised Pilot Trial

TypeinterventionalSponsorUniversity of ZurichRan2000 to 2015Enrolled40ConditionsLung CancerArmsbronchoscopy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Ultrathin Bronchoscopy for the Diagnosis of Peripheral Pulmonary Lesions: A Meta-Analysis.Respiration; international review of thoracic diseases · 2023
    Pooled it
  2. Trial
  3. Article
  4. Advances in Diagnostic Bronchoscopy.Diagnostics (Basel, Switzerland) · 2021
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Daniel FranzenDivision of Pulmonology, University Hospital Zurich, University of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Andreas H DiaconDepartment of Internal Medicine, Lung Unit, Tygerberg Academic Hospital, University of Stellenbosch, Cape Town, South Africa.
Lutz FreitagDivision of Pulmonology, University Hospital Zurich, University of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland.
Pawel T SchubertDivision of Anatomical Pathology, Tygerberg Academic Hospital, University of Stellenbosch, Cape Town, South Africa.
Colleen A WrightDivision of Anatomical Pathology, Tygerberg Academic Hospital, University of Stellenbosch, Cape Town, South Africa.
Macé M SchuurmansDivision of Pulmonology, University Hospital Zurich, University of Zurich, Raemistrasse 100, Zurich, 8091, Switzerland. mace.schuurmans@usz.ch.
Stellenbosch University · ZATygerberg Hospital · ZAUniversity Hospital of Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin bronchoscopy (UB) for this purpose is limited. To evaluate feasibility and safety of UB compared to SB for diagnosis of SPL in a TB endemic region.

methodsIn this prospective randomised trial we compared diagnostic yield and adverse events of UB with standard-size bronchoscopy (SB), both combined with fluoroscopy, in a cohort of patients with SPL located beyond the visible range of SB.

resultsWe included 40 patients (mean age 55.2 years, 45 % male) with malignant SPL (n = 16; 40 %), tuberculous SPL (n = 11; 27.5 %) and other benign SPL (n = 13; 32.5 %). Mean procedure time in UB and SB was 30.6 and 26.0 min, respectively (p = 0.15). By trend, adverse events were recorded more often with UB than with SB (30.0 vs. 5.0 %, p = 0.091), including extensive coughing (n = 2), blocked working channel (n = 2), and arterial hypertension requiring therapeutic intervention (n = 1), all with UB. The overall diagnostic yield of UB compared to SB was 55.0 % vs. 80.0 %, respectively (p = 0.18). Sensitivity for the diagnosis of malignancy of UB and SB was 50.0 % and 62.5 %, respectively (p = 0.95).

conclusionUB is not superior to SB for the evaluation of SPL in a region endemic with tuberculosis, when combined with fluoroscopic guidance only.

trial registrationClinicalTrials.gov (Identifier: NCT02490059 ).

Indexed as

BronchoscopesBiopsyBronchoscopyDiagnosis, DifferentialEndemic DiseasesEquipment DesignFemaleFluoroscopyFollow-Up StudiesHumansIncidenceLungLung NeoplasmsMaleMiddle AgedMiniaturizationDiagnostic yieldHistologyLung cancerSolitary pulmonary noduleUltrathin bronchoscopy

Identifiers

PMID27117455
PMCPMC4847358
OpenAlexW2343236503

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.